Trim43a tripartite motif-containing 43A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim43aprovided by MGI
Official Full Name: tripartite motif-containing 43Aprovided by MGI
Primary source: MGI:MGI:3645218
See related: Ensembl:ENSMUSG00000090693 AllianceGenome:MGI:3645218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm6021; EG547109
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. Is expressed in 4-cell stage embryo; 8-cell stage embryo; and early conceptus. Orthologous to several human genes including TRIM43 (tripartite motif containing 43) and TRIM43B (tripartite motif containing 43B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 9 E3.1; 9 47.24 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (88462944..88470877)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (88580891..88588824)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified a 5kb DNA fragment that covers upstream region of Trim43a as a putative promoter, which can drive the expression of mStrawberry fluorescent protein in a manner similar to endogenous Trim43 genes.
Title: Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tripartite motif-containing protein 43A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034906.3 → NP_001030078.1 tripartite motif-containing protein 43A isoform 2

See identical proteins and their annotated locations for NP_001030078.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AC163666, AK145647

Consensus CDS

CCDS23389.1

UniProtKB/Swiss-Prot

B9EIY7, Q3TL54

UniProtKB/TrEMBL

A0A087WNR2

Related

ENSMUSP00000127527.3, ENSMUST00000164661.4

Conserved Domains (3) summary

pfam00097
Location:16 → 56

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam00643
Location:88 → 129

zf-B_box; B-box zinc finger

cl02614
Location:328 → 441

SPRY; SPRY domain
NM_001357687.1 → NP_001344616.1 tripartite motif-containing protein 43A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC163666, BC141236

UniProtKB/TrEMBL

A0A087WNR2

Conserved Domains (4) summary

pfam00643
Location:88 → 129

zf-B_box; B-box zinc finger

cl02614
Location:329 → 442

SPRY; SPRY domain

cl17238
Location:14 → 56

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

cl26688
Location:9 → 101

DWNN; DWNN domain