Zbtb16 zinc finger and BTB domain containing 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb16provided by MGI
Official Full Name: zinc finger and BTB domain containing 16provided by MGI
Primary source: MGI:MGI:103222
See related: Ensembl:ENSMUSG00000066687 AllianceGenome:MGI:103222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lu; PLZF; Zfp145
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in animal organ development; central nervous system development; and regulation of hemopoiesis. Acts upstream of or within several processes, including embryonic pattern specification; limb morphogenesis; and male germ-line stem cell asymmetric division. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 8.1), subcutaneous fat pad adult (RPKM 7.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (48563097..48747525, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (48651797..48836225, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Title: Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC.
Title: Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC.
Immunohistochemistry and immunocytochemistry analysis of PLZF and VASA in mice testis during spermatogenesis.
Title: Immunohistochemistry and immunocytochemistry analysis of PLZF and VASA in mice testis during spermatogenesis.
PLZF promotes the development of asthma tolerance via affecting memory phenotypes of immune cells.
Title: PLZF promotes the development of asthma tolerance via affecting memory phenotypes of immune cells.
Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Valpha14Jalpha18 T Cell Receptor and PLZF.
Title: Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF.
Zbtb16 regulates social cognitive behaviors and neocortical development.
Title: Zbtb16 regulates social cognitive behaviors and neocortical development.
Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells.
Title: Interaction between DMRT1 and PLZF protein regulates self-renewal and proliferation in male germline stem cells.
iNKT cells with high PLZF expression are recruited into the lung via CCL21-CCR7 signaling to facilitate the development of asthma tolerance in mice.
Title: iNKT cells with high PLZF expression are recruited into the lung via CCL21-CCR7 signaling to facilitate the development of asthma tolerance in mice.
PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes.
Title: PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes.
The results identified an expression pattern of PLZF(high)c-KIT(pos) in A1 spermatogonia, while A2-A4-differentiating spermatogonia were PLZF(low)c-KIT(pos).
Title: PLZF(pos)c-KIT(pos)-delineated A(1)-A(4)-differentiating spermatogonia by subset and stage detection upon Bouin fixation.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2)
Chemically induced (other) (1) 1 citation
Targeted (5) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

37.MHAa58d1.seq (e-PCR)
- UniSTS:124209

D1S2624 (e-PCR), detects polymorphism
- UniSTS:53141

45.MMHAP28FLG6.seq (e-PCR)
- UniSTS:124572

Zbtb16 (e-PCR), detects polymorphism
- UniSTS:528069

Zbtb16 (e-PCR), detects polymorphism
- UniSTS:528070

Zbtb16 (e-PCR), detects polymorphism
- UniSTS:507334

Zbtb16 (e-PCR), detects polymorphism
- UniSTS:528071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables type 2 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephros development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 16

Names: Green's luxoid; zinc finger protein 145

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033324.3 → NP_001028496.1 zinc finger and BTB domain-containing protein 16

See identical proteins and their annotated locations for NP_001028496.1

Status: VALIDATED

Source sequence(s)

AC113548, AK142947

Consensus CDS

CCDS23158.1

UniProtKB/TrEMBL

Q3UQ17

Related

ENSMUSP00000091374.4, ENSMUST00000093852.5

Conserved Domains (3) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18205
Location:16 → 122

BTB_POZ_ZBTB16_PLZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16)
NM_001364543.1 → NP_001351472.1 zinc finger and BTB domain-containing protein 16

Status: VALIDATED

Source sequence(s)

AC113548, CT009741

Consensus CDS

CCDS23158.1

UniProtKB/TrEMBL

Q3UQ17

Related

ENSMUSP00000150887.2, ENSMUST00000216150.2

Conserved Domains (3) summary

COG5048
Location:448 → 622

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:520 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18205
Location:16 → 122

BTB_POZ_ZBTB16_PLZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16)
NM_001410497.1 → NP_001397426.1 zinc finger and BTB domain-containing protein 16

Status: VALIDATED

Source sequence(s)

AC113548, CT009741

UniProtKB/TrEMBL

Q3UQ17