Sik3 SIK family kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sik3provided by MGI
Official Full Name: SIK family kinase 3provided by MGI
Primary source: MGI:MGI:2446296
See related: Ensembl:ENSMUSG00000034135 AllianceGenome:MGI:2446296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Qsk; SIK-3; mKIAA0999; 5730525O22Rik; 9030204A07Rik
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 12.2), adrenal adult (RPKM 10.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 25.36 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45924099..46135492)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (46012820..46224194)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1 Expression.
Title: Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA(A)R α1 Expression.
Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
Title: Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
Title: Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
Face validation and pharmacologic analysis of Sik3[Sleepy] mutant mouse as a possible model of idiopathic hypersomnia.
Title: Face validation and pharmacologic analysis of Sik3(Sleepy) mutant mouse as a possible model of idiopathic hypersomnia.
SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Title: SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Title: Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
Title: Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
Title: The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
Salt inducible kinases 2 and 3 are required for thymic T cell development.
Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Title: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI059153 (e-PCR)
- UniSTS:244511

AI846254 (e-PCR)
- UniSTS:164402

RH126838 (e-PCR)
- UniSTS:209748

REN72864 (e-PCR)
- UniSTS:397664

AI447252 (e-PCR)
- UniSTS:159870

RH126001 (e-PCR)
- UniSTS:162713

D9Jpk1 (e-PCR), detects polymorphism
- UniSTS:142746

AI849445 (e-PCR)
- UniSTS:165625

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase SIK3

Names: salt-inducible kinase 3; serine/threonine-protein kinase QSK

NP_081774.3

EC 2.7.11.1

XP_006510653.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027498.3 → NP_081774.3 serine/threonine-protein kinase SIK3

Status: VALIDATED

Source sequence(s)

AK129257, BC080688, BG229919, CJ171970

Consensus CDS

CCDS23140.2

UniProtKB/Swiss-Prot

E9PU87, Q641L5, Q66JZ5, Q6P4S6, Q6ZQ09, Q8K075, Q9CYD5

UniProtKB/TrEMBL

F6S7W6

Related

ENSMUSP00000121032.2, ENSMUST00000126865.8

Conserved Domains (3) summary

smart00220
Location:66 → 317

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14410
Location:346 → 390

UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)

cd14071
Location:65 → 317

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

45924099..46135492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510590.4 → XP_006510653.1 serine/threonine-protein kinase SIK3 isoform X1

UniProtKB/TrEMBL

F6S7W6

Related

ENSMUSP00000112749.3, ENSMUST00000120463.9

Conserved Domains (2) summary

cd14410
Location:346 → 390

UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)

cd14071
Location:65 → 317

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases