Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3r3provided by MGI
Official Full Name: phosphoinositide-3-kinase regulatory subunit 3provided by MGI
Primary source: MGI:MGI:109277
See related: Ensembl:ENSMUSG00000028698 Ensembl:ENSMUSG00000111410 AllianceGenome:MGI:109277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p55; p55pik
Summary: Enables 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 19.3), CNS E14 (RPKM 19.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.1 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116078593..116160253)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116221400..116303056)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
Title: p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
PIK3R3 regulates the expression of PPAR-alpha.The activation of PIK3R3 decreased hepatosteatosis.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism.
Title: PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
These data support an important role for the p55gamma subunit of PI3K in ALK-induced cell migration during brain development
Title: Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators.
p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kappaB pathway.
Title: p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235010

AA414954 (e-PCR)
- UniSTS:207661

D4Mit333 (e-PCR), detects polymorphism
- UniSTS:130123

RH124538 (e-PCR)
- UniSTS:161360

Pik3r3 (e-PCR), detects polymorphism
- UniSTS:527490

RH126266 (e-PCR)
- UniSTS:162974

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit gamma

Names: PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355584.2 → NP_001342513.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

AL670603

Consensus CDS

CCDS18509.1

UniProtKB/Swiss-Prot

Q64143

UniProtKB/TrEMBL

Q3TST3, Q3UXE9

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001355585.1 → NP_001342514.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CN535899, CV558350, CV562336

Consensus CDS

CCDS18509.1

UniProtKB/Swiss-Prot

Q64143

UniProtKB/TrEMBL

Q3TST3, Q3UXE9

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001355586.1 → NP_001342515.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

Status: VALIDATED

Source sequence(s)

AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CV558350, CV562336

UniProtKB/TrEMBL

Q3TST3

Related

ENSMUSP00000150163.2, ENSMUST00000216692.2

Conserved Domains (3) summary

cd09930
Location:307 → 410

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:15 → 123

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:128 → 288

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001421303.1 → NP_001408232.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

Status: VALIDATED

Source sequence(s)

AL670603
NM_001421304.1 → NP_001408233.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

Status: VALIDATED

Source sequence(s)

AL670603
NM_001421305.1 → NP_001408234.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

Status: VALIDATED

Source sequence(s)

AL670603
NM_001421306.1 → NP_001408235.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

Status: VALIDATED

Source sequence(s)

AL670603
NM_181585.7 → NP_853616.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

See identical proteins and their annotated locations for NP_853616.1

Status: VALIDATED

Source sequence(s)

AL670603

Consensus CDS

CCDS18509.1

UniProtKB/Swiss-Prot

Q64143

UniProtKB/TrEMBL

Q3TST3, Q3UXE9

Related

ENSMUSP00000030464.8, ENSMUST00000030464.14

Conserved Domains (3) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

116078593..116160253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502860.5 → XP_006502923.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

See identical proteins and their annotated locations for XP_006502923.1

UniProtKB/TrEMBL

Q3TST3

Conserved Domains (3) summary

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

cl15255
Location:351 → 396

SH2; Src homology 2 (SH2) domain
XM_006502859.4 → XP_006502922.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

See identical proteins and their annotated locations for XP_006502922.1

UniProtKB/TrEMBL

Q3TST3

Conserved Domains (3) summary

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

cl15255
Location:351 → 396

SH2; Src homology 2 (SH2) domain
XM_030253316.2 → XP_030109176.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

Conserved Domains (3) summary

cd09942
Location:15 → 123

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:128 → 288

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

cl15255
Location:307 → 352

SH2; Src homology 2 (SH2) domain