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    Myom2 myomesin 2 [ Mus musculus (house mouse) ]

    Gene ID: 17930, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Myom2provided by MGI
    Official Full Name
    myomesin 2provided by MGI
    Primary source
    MGI:MGI:1328358
    See related
    Ensembl:ENSMUSG00000031461 AllianceGenome:MGI:1328358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity and kinase binding activity. Acts upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including heart; limb; notochord; paraxial mesenchyme; and skeletal musculature. Orthologous to human MYOM2 (myomesin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 109.4), mammary gland adult (RPKM 11.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Myom2 in Genome Data Viewer
    Location:
    8 A1.1; 8 7.63 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15107653..15183410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15057653..15133420)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35340 Neighboring gene expressed sequence BB014433 Neighboring gene STARR-seq mESC enhancer starr_20806 Neighboring gene STARR-seq mESC enhancer starr_20807 Neighboring gene predicted gene, 24231 Neighboring gene predicted gene, 35392

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of the gene encoding murine M-protein, a sarcomere-specific member of the immunoglobulin superfamily. Steiner F, et al. Genomics, 1998 Apr 1. PMID 9570952
    2. Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice. Carlsson L, et al. Exp Cell Res, 1999 Aug 25. PMID 10438587
    3. Establishment of cardiac cytoarchitecture in the developing mouse heart. Hirschy A, et al. Dev Biol, 2006 Jan 15. PMID 16337936
    4. Myomesin 3, a novel structural component of the M-band in striated muscle. Schoenauer R, et al. J Mol Biol, 2008 Feb 15. PMID 18177667
    5. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Hayashi S, et al. Elife, 2016 Oct 15. PMID 27743478, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141540, MGC141541

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myomesin-2
    Names
    skeletal muscle 165kD protein
    skeletal muscle 165kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414182.1 → NP_001401111.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    2. NM_001414183.1 → NP_001401112.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    3. NM_001414184.1 → NP_001401113.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    4. NM_001414185.1 → NP_001401114.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    5. NM_001414186.1 → NP_001401115.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    6. NM_001414187.1 → NP_001401116.1  myomesin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      UniProtKB/TrEMBL
      Q14BI5

    7. NM_001414188.1 → NP_001401117.1  myomesin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235

    8. NM_001414189.1 → NP_001401118.1  myomesin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235

    9. NM_001414190.1 → NP_001401119.1  myomesin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235

    10. NM_008664.3 → NP_032690.2  myomesin-2 isoform 1

      See identical proteins and their annotated locations for NP_032690.2

      Status: VALIDATED

      Source sequence(s)
      AC124604, AC125235
      Consensus CDS
      CCDS22123.1
      UniProtKB/TrEMBL
      Q14BI5, Q3UQS9
      Related
      ENSMUSP00000033842.4, ENSMUST00000033842.4
      Conserved Domains (6) summary
      cd05891
      Location:1344 → 1435
      IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
      smart00409
      Location:940 → 995
      IG; Immunoglobulin
      cd00063
      Location:383 → 475
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:295 → 299
      Ig; Ig strand B [structural motif]
      cd20951
      Location:154 → 247
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:290 → 372
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      15107653..15183410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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