U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DIC1 Dic1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851063, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    DIC1
    Gene description
    Dic1p
    Primary source
    FungiDB:YLR348C
    Locus tag
    YLR348C
    See related
    SGD:S000004340; AllianceGenome:SGD:S000004340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dicarboxylic acid transmembrane transporter activity. Involved in dicarboxylic acid transport. Located in mitochondrial envelope. Used to study childhood onset epileptic encephalopathy; mitochondrial DNA depletion syndrome; and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome and paraganglioma. Orthologous to several human genes including SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DIC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (826977..827873, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Cis1p Neighboring gene karyopherin beta Neighboring gene sphingolipid homeostasis protein ORM2 Neighboring gene putative hydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A protein structure prediction service in the ProGenGrid system. Mirto M, et al. Stud Health Technol Inform, 2008. PMID 18560115
    2. Biogenesis of yeast dicarboxylate carrier: the carrier signature facilitates translocation across the mitochondrial outer membrane. Zara V, et al. J Cell Sci, 2007 Dec 1. PMID 18032784
    3. Topography of the active site of the Saccharomyces cerevisiae plasmalemmal dicarboxylate transporter studied using lipophilic derivatives of its substrates. Aliverdieva DA, et al. Biochemistry (Mosc), 2007 Mar. PMID 17447879
    4. The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Palmieri L, et al. Mol Microbiol, 1999 Jan. PMID 10027973
    5. Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product. Kakhniashvili D, et al. J Biol Chem, 1997 Feb 14. PMID 9020177

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. each module of the dicarboxylate carrier contains sufficient targeting information for its transport across the outer mitochondrial membrane
      Title: The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dicarboxylic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Dic1p
    NP_013452.1
    • Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      826977..827873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182237.1 → NP_013452.1  TPA: Dic1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY7, P87332, Q06143
      UniProtKB/TrEMBL
      A0A6A5PWS6, A7A1M7, B3RHL8, C7GRX4, C8ZDV6, G2WJG7, N1NZN7
      Conserved Domains (1) summary
      pfam00153
      Location:20 → 94
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06143.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous