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    GTB1 Gtb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851807, updated on 17-May-2024

    Summary

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    Gene symbol
    GTB1
    Gene description
    Gtb1p
    Primary source
    FungiDB:YDR221W
    Locus tag
    YDR221W
    See related
    SGD:S000002629; AllianceGenome:SGD:S000002629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to alpha-1,4-glucosidase activity. Involved in N-glycan processing and polysaccharide biosynthetic process. Located in endoplasmic reticulum lumen. Part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GTB1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (907330..909438)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene septin SPR28 Neighboring gene Mfb1p Neighboring gene uncharacterized protein Neighboring gene Crf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role for Gtb1p in glucose trimming of N-linked glycans. Quinn RP, et al. Glycobiology, 2009 Dec. PMID 19542522, Free PMC Article
    2. Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. Wilkinson BM, et al. J Biol Chem, 2006 Mar 10. PMID 16373354
    3. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
    4. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Freije BJ, et al. Chem Res Toxicol, 2022 Feb 21. PMID 35084835, Free PMC Article
    5. Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Brooks MA, et al. Structure, 2010 Sep 8. PMID 20826334

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both the MRH and G2B domains of Gtb1p contribute to the Glc2 trimming event but that the MRH domain is essential for Glc1 trimming.
      Title: A novel role for Gtb1p in glucose trimming of N-linked glycans.
    2. GTB1 is required for normal glycoprotein biogenesis; Gtb1p is essential for cleavage of the final glucose.
      Title: Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glucosidase II complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gtb1p
    NP_010507.3
    • Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      907330..909438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180529.3 → NP_010507.3  TPA: Gtb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010507.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSK3, Q04924
      UniProtKB/TrEMBL
      A0A8H8UNC7, A6ZYH5, B3LG66, B5VGA9, C7GVD0, N1P6V5
      Conserved Domains (3) summary
      PRK05771
      Location:127 → 300
      PRK05771; V-type ATP synthase subunit I; Validated
      pfam12999
      Location:28 → 187
      PRKCSH-like; Glucosidase II beta subunit-like
      cl06793
      Location:635 → 695
      PRKCSH; Glucosidase II beta subunit-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04924.1

    Gene LinkOut

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