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    YGL082W uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852798, updated on 13-Apr-2024

    Summary

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    Gene symbol
    YGL082W
    Gene description
    uncharacterized protein
    Primary source
    SGD:S000003050
    Locus tag
    YGL082W
    See related
    AllianceGenome:SGD:S000003050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity and cysteine-type carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human MINDY1 (MINDY lysine 48 deubiquitinase 1) and MINDY2 (MINDY lysine 48 deubiquitinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (355827..356972)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene O-acyltransferase Neighboring gene Scy1p Neighboring gene uncharacterized protein Neighboring gene pyruvate transporter MPC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Trueblood CE, et al. Mol Cell Biol, 2000 Jun. PMID 10825201, Free PMC Article
    2. Rtn1p is involved in structuring the cortical endoplasmic reticulum. De Craene JO, et al. Mol Biol Cell, 2006 Jul. PMID 16624861, Free PMC Article
    3. α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast. Popova B, et al. Cells, 2021 Aug 28. PMID 34571878, Free PMC Article
    4. The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Delom F, et al. Proteomics, 2006 May. PMID 16622836
    5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_011433.3
    • hypothetical protein; MINDY family deubiquitinase that does not appear to contain catalytic activity; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; not an essential gene; YGL082W has a paralog, YPL191C, that arose from the whole genome duplication; ortholog of human MINDY1/FAM63A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      355827..356972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180947.3 → NP_011433.3  TPA: uncharacterized protein YGL082W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011433.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU62, P53155, Q6Q536
      UniProtKB/TrEMBL
      A0A8H4F9W1, A6ZU97, B3LHE8, C7GW34, C8Z8G5, N1P9Q4
      Conserved Domains (1) summary
      pfam04424
      Location:35 → 147
      MINDY_DUB; MINDY deubiquitinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53155.1

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