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    AP-2mu Adaptor Protein complex 2, mu subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42642, updated on 27-Mar-2024

    Summary

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    Official Symbol
    AP-2muprovided by FlyBase
    Official Full Name
    Adaptor Protein complex 2, mu subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263351
    Locus tag
    Dmel_CG7057
    See related
    AllianceGenome:FB:FBgn0263351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey50; anon-WO0172774.104; AP-50; AP2mu2; AP50; apm4; cg7057; CG7057; Dmel\CG7057; Dmu2; MENE (3R)-D; MENE(3R)-D; mu2; mu2-ada
    Summary
    Enables clathrin adaptor activity. Involved in dsRNA transport and endocytosis. Part of AP-2 adaptor complex. Is expressed in several structures, including adult head; circulatory system; embryonic neuroblast; embryonic/larval midgut; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AP-2mu in Genome Data Viewer
    Location:
    94A15-94A16; 3-74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22462455..22464603)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18288177..18290325)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 7 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylethanolamine-binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. Mullins C, et al. Mol Gen Genet, 1999 Oct. PMID 10589826
    2. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. Worby CA, et al. J Biol Chem, 2001 Nov 9. PMID 11546816
    3. Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary. Peters NC, et al. Dev Biol, 2016 Jan 1. PMID 26542010, Free PMC Article
    4. Stoned B mediates sorting of integral synaptic vesicle proteins. Mohrmann R, et al. Neuroscience, 2008 Jun 2. PMID 18436388, Free PMC Article
    5. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Jullien-Flores V, et al. J Cell Sci, 2000 Aug. PMID 10910768

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dsRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adaptor protein complex 2, mu subunit
    Names
    AP-2mu-PA
    AP-2mu-PB
    AP-2mu-PC
    AP-50
    CG7057-PA
    CG7057-PB
    CG7057-PC
    adaptor protein complex 2
    clathrin AP-2 complex
    mu2 medium chain of adaptin AP2
    mu2-adaptin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22462455..22464603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142792.5 → NP_651049.3  adaptor protein complex 2, mu subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651049.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62530
      Related
      FBpp0083646
      Conserved Domains (2) summary
      cd09251
      Location:166 → 436
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:1 → 140
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

    2. NM_001170215.2 → NP_001163686.1  adaptor protein complex 2, mu subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62530
      Conserved Domains (2) summary
      cd09251
      Location:166 → 436
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:1 → 140
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

    3. NM_170015.3 → NP_732744.1  adaptor protein complex 2, mu subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62530
      Related
      FBpp0083645
      Conserved Domains (2) summary
      cd09251
      Location:166 → 436
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:1 → 140
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62530 O62530

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