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    hoe1 hoepel1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 249663, updated on 11-Apr-2024

    Summary

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    Official Symbol
    hoe1provided by FlyBase
    Official Full Name
    hoepel1provided by FlyBase
    Primary source
    FLYBASE:FBgn0041150
    Locus tag
    Dmel_CG12787
    See related
    AllianceGenome:FB:FBgn0041150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02636; CG11918; CG12787; CG2831; Dmel\CG12787; hoe; hoe-1; Hoe1
    Summary
    Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    25B3-25B3; 2-14 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4908581..4932384, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4908581..4932384, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene snustorr snarlik Neighboring gene hoepel2 Neighboring gene Salivary gland secretion 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Translational control via protein-regulated upstream open reading frames. Medenbach J, et al. Cell, 2011 Jun 10. PMID 21663794
    2. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, et al. Cell, 2018 Jul 26. PMID 29909983, Free PMC Article
    3. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Baker BM, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34074789, Free PMC Article
    4. Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Stielow B, et al. Mol Cell, 2008 Mar 28. PMID 18374648
    5. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Liu LP, et al. Nat Genet, 2005 Dec. PMID 16258543

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4923234-4918233 mobile_element_type = transposon:jockey{}307

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    hoepel1
    Names
    CG12787-PA
    CG12787-PB
    CG12787-PC
    CG12787-PD
    CG12787-PE
    CG12787-PF
    CG12787-PH
    CG12787-PI
    CG12787-PJ
    hoe1-PA
    hoe1-PB
    hoe1-PC
    hoe1-PD
    hoe1-PE
    hoe1-PF
    hoe1-PH
    hoe1-PI
    hoe1-PJ
    hoepel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4908581..4932384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298678.1 → NP_001285607.1  hoepel1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX6, Q9VR47
      Conserved Domains (2) summary
      COG1055
      Location:345 → 839
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:349 → 837
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    2. NM_135032.2 → NP_608876.1  hoepel1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX6, Q9VR47
      Related
      FBpp0077087
      Conserved Domains (2) summary
      COG1055
      Location:345 → 839
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:349 → 837
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    3. NM_164603.2 → NP_723024.2  hoepel1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723024.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I930, Q8IGX6, Q9VR46
      Related
      FBpp0077086
      Conserved Domains (2) summary
      COG1055
      Location:311 → 805
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:315 → 803
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    4. NM_175968.2 → NP_787982.1  hoepel1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I930, Q8IGX6, Q9VR46
      Related
      FBpp0077091
      Conserved Domains (2) summary
      COG1055
      Location:311 → 805
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:315 → 803
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    5. NM_001273131.1 → NP_001260060.1  hoepel1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I930, Q8IGX6, Q9VR46
      Conserved Domains (2) summary
      COG1055
      Location:311 → 805
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:315 → 803
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    6. NM_175966.2 → NP_787980.1  hoepel1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787980.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I930, Q8IGX6, Q9VR46
      Related
      FBpp0077089
      Conserved Domains (2) summary
      COG1055
      Location:311 → 805
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:315 → 803
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    7. NM_001273130.1 → NP_001260059.1  hoepel1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAH7
      Conserved Domains (2) summary
      COG1055
      Location:157 → 651
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:161 → 649
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    8. NM_175967.2 → NP_787981.1  hoepel1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I930, Q8IGX6, Q9VR46
      Related
      FBpp0077090
      Conserved Domains (2) summary
      COG1055
      Location:311 → 805
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:315 → 803
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...

    9. NM_135031.4 → NP_608875.1  hoepel1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX6, Q9Y163
      Related
      FBpp0077088
      Conserved Domains (2) summary
      COG1055
      Location:302 → 796
      ArsB; Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]
      cd01116
      Location:306 → 794
      P_permease; Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAH7 F0JAH7
    Q8I930 Q8I930
    Q8IGX6 Q8IGX6
    Q9VR47 Q9VR47
    Q9Y163 Q9Y163

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