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    nAChRalpha2 nicotinic Acetylcholine Receptor alpha2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42919, updated on 11-Apr-2024

    Summary

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    Official Symbol
    nAChRalpha2provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha2provided by FlyBase
    Primary source
    FLYBASE:FBgn0000039
    Locus tag
    Dmel_CG6844
    See related
    AllianceGenome:FB:FBgn0000039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acr96Ab; AcrE; alpha2; alpha[[2]]; CG6844; CG6844-PA; da2; Da2; Dalpha; Dalpha2; Dalpha2/SAD; Dmalpha2; Dmel\CG6844; D[a2]; nAChR; nAChR Dalpha2; nAChR-alpha96Ab; nAChRa2; nAChRalpha-96A; nAchRalpha-96Ab; nAcr96Ab; nAcRalpha-96Ab; nAcRs; sad; SAD
    Summary
    Contributes to acetylcholine receptor activity and acetylcholine-gated cation-selective channel activity. Involved in cation transmembrane transport and cholinergic synaptic transmission. Part of acetylcholine-gated channel complex. Is expressed in several structures, including central nervous system; ectoderm anlage; extended germ band embryo; germ layer; and ventral midline of embryo. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); lung cancer; multiple pterygium syndrome; and nicotine dependence. Orthologous to several human genes including CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96A3-96A3; 3-85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24485428..24491147)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20311150..20316869)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45649 Neighboring gene uncharacterized protein Neighboring gene mir-1017 stem loop Neighboring gene nicotinic Acetylcholine Receptor beta2 Neighboring gene DZIP1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors. Tomizawa M, et al. Insect Biochem Mol Biol, 2005 Dec. PMID 16291090
    2. Super agonist actions of clothianidin and related compounds on the SAD beta 2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Ihara M, et al. Biosci Biotechnol Biochem, 2004 Mar. PMID 15056916
    3. Insecticidal and neural activities of candidate photoaffinity probes for neonicotinoid binding sites. Matsuda K, et al. Biosci Biotechnol Biochem, 2001 Jul. PMID 11515536
    4. Structure and developmental expression of the D alpha 2 gene encoding a novel nicotinic acetylcholine receptor protein of Drosophila melanogaster. Jonas P, et al. FEBS Lett, 1990 Aug 20. PMID 2117557
    5. Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit. Sawruk E, et al. EMBO J, 1990 Sep. PMID 1697262, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, cholinergic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha2
    Names
    CG6844-PA
    CG6844-PB
    Dalpha2
    Dalpha2 nicotimic acetylcholine receptor
    SAD
    drosophila alpha-like subunit 2
    nAChRalpha2-PA
    nAChRalpha2-PB
    nicotinic acetylcholine receptor alpha 96Ab
    nicotinic acetylcholine receptor alpha subunit gene at 96AB
    nicotinic acetylcholine receptor alpha-2
    second alpha-like subunit of drosophila

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24485428..24491147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079758.3 → NP_524482.1  nicotinic acetylcholine receptor alpha2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17644, Q0KI18, Q9VC73
      Related
      FBpp0084023
      Conserved Domains (2) summary
      TIGR00860
      Location:47 → 544
      LIC; Cation transporter family protein
      cd19031
      Location:44 → 263
      LGIC_ECD_nAChR_proto_alpha-like; extracellular domain of nicotinic acetylcholine receptor subunit alpha-like found in protostomia

    2. NM_170146.2 → NP_733001.1  nicotinic acetylcholine receptor alpha2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17644, Q0KI18, Q9VC73
      Related
      FBpp0084024
      Conserved Domains (2) summary
      TIGR00860
      Location:47 → 544
      LIC; Cation transporter family protein
      cd19031
      Location:44 → 263
      LGIC_ECD_nAChR_proto_alpha-like; extracellular domain of nicotinic acetylcholine receptor subunit alpha-like found in protostomia
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17644.1 P17644

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