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    ana1 anastral spindle 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42927, updated on 26-Apr-2024

    Summary

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    Official Symbol
    ana1provided by FlyBase
    Official Full Name
    anastral spindle 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262167
    Locus tag
    Dmel_CG6631
    See related
    AllianceGenome:FB:FBgn0262167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ana 1; Ana-1; Ana1; ANA1; CG6631; Dmel\CG6631; mecB
    Summary
    Involved in microtubule cytoskeleton organization and neuron development. Located in centriole and ciliary basal body. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96A6-96A6; 3-85 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24530576..24536395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20356298..20362117)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Juvenile hormone binding protein 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene CF transmembrane conductance regulator Neighboring gene Extended synaptotagmin-like protein 2 Neighboring gene transfer RNA:Aspartic acid-GTC 1-11 Neighboring gene small nuclear RNA U6 at 96A a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly. Wong SS, et al. EMBO J, 2022 Jun 1. PMID 35505659, Free PMC Article
    2. Conserved molecular interactions in centriole-to-centrosome conversion. Fu J, et al. Nat Cell Biol, 2016 Jan. PMID 26595382, Free PMC Article
    3. Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster. Jo KH, et al. Cells, 2019 Aug 5. PMID 31387336, Free PMC Article
    4. Centrobin is essential for C-tubule assembly and flagellum development in Drosophila melanogaster spermatogenesis. Reina J, et al. J Cell Biol, 2018 Jul 2. PMID 29712734, Free PMC Article
    5. Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis. Riparbelli MG, et al. Cell Cycle, 2014. PMID 24802643, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM.
      Title: Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM.
    2. Ana1 helps recruit Polo to centrioles to promote mitotic PCM assembly and centriole elongation.
      Title: Ana1 helps recruit Polo to centrioles to promote mitotic PCM assembly and centriole elongation.
    3. By halfway through pupal life, the centriole number decreases and structural defects, ranging from being incomplete or lacking B-tubules, are detected. Asl, Ana1 and Sas-4 are still present, suggesting that the centriole integrity does not depend on these proteins.
      Title: The developing Drosophila eye - a new model to study centriole reduction.
    4. ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibly incorporated into centrioles during their assembly and appears to play a more important role in maintaining Asl at centrioles than in initially recruiting Asl to centrioles...the N-terminal region of Ana1 (amino acids 1-935) is required to target Ana1 to centrioles through a direct interaction with Cep135, whereas the C-terminal region of Ana1.
      Title: Drosophila Ana1 is required for centrosome assembly and centriole elongation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anastral spindle 1
    Names
    CG6631-PA
    CG6631-PC
    ana1-PA
    ana1-PC
    anastral spindle phenotype 1
    mechanosensory B
    mechanosensory mutant B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24530576..24536395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170148.3 → NP_733008.2  anastral spindle 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733008.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC64
      Conserved Domains (3) summary
      pfam11235
      Location:299 → 500
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam14179
      Location:436 → 485
      YppG; YppG-like protein
      cl21478
      Location:704 → 815
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_143011.3 → NP_651268.1  anastral spindle 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC64
      Related
      FBpp0084029
      Conserved Domains (3) summary
      pfam11235
      Location:299 → 500
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam14179
      Location:436 → 485
      YppG; YppG-like protein
      cl21478
      Location:704 → 815
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961D7 Q961D7
    Q9VC64 Q9VC64

    Gene LinkOut

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    Other Literature Sources
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