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    CG7222 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36138, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG7222provided by FlyBase
    Primary source
    FLYBASE:FBgn0033551
    Locus tag
    Dmel_CG7222
    See related
    AllianceGenome:FB:FBgn0033551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7222
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Is expressed in adult head and organism. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG7222 in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10813405..10815781)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6700910..6703286)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nop10 ribonucleoprotein Neighboring gene Methyl methanesulfonate sensitivity 4 Neighboring gene uncharacterized protein Neighboring gene diego Neighboring gene Proteasome beta5 subunit Neighboring gene Lsm10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Schroeder AM, et al. Hum Mol Genet, 2019 Dec 1. PMID 31625562, Free PMC Article
    2. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
    3. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
    4. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7222-PA
    CG7222-PB
    NP_001286295.1
    NP_610613.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10813405..10815781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299366.1 → NP_001286295.1  uncharacterized protein Dmel_CG7222, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2B1
      Conserved Domains (1) summary
      pfam05903
      Location:37 → 181
      Peptidase_C97; PPPDE putative peptidase domain

    2. NM_136769.3 → NP_610613.1  uncharacterized protein Dmel_CG7222, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2B1
      Related
      FBpp0087318
      Conserved Domains (1) summary
      pfam05903
      Location:37 → 181
      Peptidase_C97; PPPDE putative peptidase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2B1 Q7K2B1

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