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    Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 26908, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eif2s3yprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linkedprovided by MGI
    Primary source
    MGI:MGI:1349430
    See related
    Ensembl:ENSMUSG00000069049 AllianceGenome:MGI:1349430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spy; Tfy; Eif-2gy
    Summary
    Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 11.4), CNS E14 (RPKM 7.7) and 17 other tissues See more
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    Genomic context

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    Location:
    Y; Ypter
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1010562..1049136)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1010562..1049134)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48294 Neighboring gene lysine demethylase 5D Neighboring gene STARR-seq mESC enhancer starr_48295 Neighboring gene STARR-seq mESC enhancer starr_48296 Neighboring gene nuclear encoded rRNA 5S 1 Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
      Title: Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
    2. The Role of Eif2s3y in Mouse Spermatogenesis and ESC.
      Title: The Role of Eif2s3y in Mouse Spermatogenesis and ESC.
    3. Eif2s3y regulates the proliferation of spermatogonial stem cells via Wnt6/<beta>-catenin signaling pathway.
      Title: Eif2s3y regulates the proliferation of spermatogonial stem cells via Wnt6/<beta>-catenin signaling pathway.
    4. Study highlighted novel roles of EIF2S3Y in the pluripotency maintenance and proliferation control of ES cells, which would provide an efficient model to study germ cell generation as well as cancer development using ES cells.
      Title: EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells.
    5. Eif2s3y can be replaced by transgenic overexpression of its X chromosome-encoded homolog Eif2s3x. This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
      Title: Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.
    6. this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
      Title: Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.
    7. Data from knockout mice suggest that spermiogenesis can be initiated whether or not second meiotic division has taken place, and even when the only Y genes present are Eif2s3y and Sry.
      Title: Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3, Y-linked
    Names
    eIF-2-gamma Y
    eukaryotic translation initiation factor 2 subunit gamma, Y-linked
    spermatogenesis Y
    spermatogonial proliferation factor
    NP_001344023.1
    NP_036141.1
    XP_006531673.1
    XP_011246895.1
    XP_030107429.1
    XP_036018085.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357094.1 → NP_001344023.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC145392
      UniProtKB/TrEMBL
      Q3U5H6
      Conserved Domains (1) summary
      PTZ00327
      Location:1 → 287
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    2. NM_012011.2 → NP_036141.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1

      See identical proteins and their annotated locations for NP_036141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC145392, AI661184, AK009448, BY711372
      Consensus CDS
      CCDS30542.1
      UniProtKB/Swiss-Prot
      Q9Z0N2
      UniProtKB/TrEMBL
      Q9D791
      Related
      ENSMUSP00000088736.4, ENSMUST00000091197.4
      Conserved Domains (4) summary
      cd01888
      Location:42 → 248
      eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
      PTZ00327
      Location:13 → 466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
      cd03688
      Location:249 → 362
      eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
      cd15490
      Location:365 → 459
      eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      1010562..1049136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251569.2 → XP_030107429.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X3

      UniProtKB/TrEMBL
      Q3U5H6
      Conserved Domains (1) summary
      PTZ00327
      Location:1 → 273
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    2. XM_011248593.3 → XP_011246895.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

      See identical proteins and their annotated locations for XP_011246895.1

      UniProtKB/TrEMBL
      Q3UDF8
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 452
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    3. XM_036162192.1 → XP_036018085.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

      UniProtKB/TrEMBL
      Q3UDF8
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 452
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    4. XM_006531610.4 → XP_006531673.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X2

      See identical proteins and their annotated locations for XP_006531673.1

      UniProtKB/TrEMBL
      Q3U5H6
      Conserved Domains (1) summary
      PTZ00327
      Location:1 → 287
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    RNA

    1. XR_004940598.1 RNA Sequence

    2. XR_879402.4 RNA Sequence

    3. XR_004940597.1 RNA Sequence

    4. XR_004940596.1 RNA Sequence

    5. XR_003953252.1 RNA Sequence

    6. XR_001782883.2 RNA Sequence

    7. XR_001782884.2 RNA Sequence

    8. XR_001782885.2 RNA Sequence

    9. XR_001782886.2 RNA Sequence

    10. XR_388245.2 RNA Sequence

    11. XR_001782887.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0N2.2 GenPept UniProtKB/Swiss-Prot:Q9Z0N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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