gbb glass bottom boat [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gbbprovided by FlyBase
Official Full Name: glass bottom boatprovided by FlyBase
Primary source: FLYBASE:FBgn0024234
Locus tag: Dmel_CG5562
See related: AllianceGenome:FB:FBgn0024234
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 60A; BMP; CG5562; Dm-GBB; Dmel\CG5562; DmGBB; Gbb; GBB; gbb-60A; Gbb-60A; gcn; l(2)60A-J; SixtyA; TGF-b; Tgfb-60; tgfb-60A; Tgfbeta-60A; TGFbeta-60A; vgr/60A
Summary: Enables protein heterodimerization activity and receptor ligand activity. Involved in several processes, including animal organ development; modulation of chemical synaptic transmission; and synapse organization. Located in dense core granule. Is active in extracellular space. Is expressed in several structures, including embryonic/larval gut; germ layer; gonad; imaginal disc; and presumptive embryonic/larval system. Used to study diabetes mellitus and obesity. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including BMP5 (bone morphogenetic protein 5); BMP7 (bone morphogenetic protein 7); and BMP8A (bone morphogenetic protein 8a). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 60A3-60A4; 2-105 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23851562..23853247)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19739085..19740770)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth.
Title: Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth.
The results indicate that high-fat diet-induced Gbb signaling provokes insulin resistance by increasing tribbles expression.
Title: High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression.
Dpp and Gbb are produced by enterocytes and act in conjunction to promote intestinal stem cell self-renewal by antagonizing Notch signaling.
Title: Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut.
Dpp/Gbb signaling is required for normal intestinal regeneration during infection.
Title: Dpp/Gbb signaling is required for normal intestinal regeneration during infection.
propose that Gbb/Cmpy corelease from presynaptic terminals defines a neuronal protransmission signal
Title: Crimpy enables discrimination of presynaptic and postsynaptic pools of a BMP at the Drosophila neuromuscular junction.
Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling
Title: Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage.
Glial Mav modulates muscle expression of Gbb.
Title: Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.
Data indicate that Gbb38, the large ligand form of the glass bottom boat (Gbb) exhibited greater signaling activity and a longer range than the shorter form Gbb15.
Title: A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.
Studies indicate that glass bottom boat (Gbb) can be processed singly at a prodomain site or a main site to generate two active isoforms, Gbb15 and Gbb38.
Title: You're going to need a bigger (glass bottom) boat.
Data demonstrate that crimpy (cmpy; CG13253) limits neuronal Gbb activity to permit appropriate regulation of neuromuscular junction growth.
Title: Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval fat body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of synapse structure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retrograde trans-synaptic signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glass bottom boat

Names: CG5562-PA; CG5562-PB; bone morphogenetic protein; bone morphogenic protein; gbb-PA; gbb-PB; glass bottom boat-60A; glass-bottom boat; glass-bottomed boat; transforming growth factor beta at 60A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23851562..23853247

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057992.3 → NP_477340.1 glass bottom boat, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477340.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27091, Q9W1I4

UniProtKB/TrEMBL

A0A0B4LGA7

Related

FBpp0072036

Conserved Domains (2) summary

smart00204
Location:354 → 455

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:44 → 305

TGFb_propeptide; TGF-beta propeptide
NM_001299857.1 → NP_001286786.1 glass bottom boat, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286786.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27091, Q9W1I4

UniProtKB/TrEMBL

A0A0B4LGA7

Conserved Domains (2) summary

smart00204
Location:354 → 455

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:44 → 305

TGFb_propeptide; TGF-beta propeptide