Stx1b syntaxin 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx1bprovided by RGD
Official Full Name: syntaxin 1Bprovided by RGD
Primary source: RGD:3784
See related: Ensembl:ENSRNOG00000019193 AllianceGenome:RGD:3784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stx2; Stx1b2
Summary: Enables protein domain specific binding activity and signaling receptor binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and regulation of exocytosis. Located in presynaptic active zone membrane. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 280.3) and Uterus (RPKM 10.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191846016..191864878, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182415544..182434385, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199251842..199270465, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that low syntaxin and SNAP-25 cleavage could reflect poor expression of a particular Botulinum neurotoxin mutant.
Title: Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin.
syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network
Title: Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments.
Deletion analysis showed that the syntaxin-2/3 (or Munc18-1/2)-binding site is a linker domain of Slp4-a.
Title: Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.
expression and localization of plasma membrane syntaxins which may contribute to the trafficking phenotype of retinal pigment epithelial cells
Title: Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.
Syntaxin 2 is expressed in alveolar type II cells of the lung; evidence supports its functional role in exocytosis of lung surfactant by alveolar type II cells.
Title: Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Arb21 (e-PCR), detects polymorphism
- UniSTS:227005

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	IEA Inferred from Electronic Annotation more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macropinocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of synaptic vesicle recycling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of spontaneous neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle priming	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle priming	ISS Inferred from Sequence or Structural Similarity more info
involved_in spontaneous neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle docking	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking involved in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking involved in exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syntaxin-1B

Names: P35B; Syntaxin 2; syntaxin 1B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.