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    RT1-CE16 RT1 class I, locus CE16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 414819, updated on 13-Apr-2024

    Summary

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    Symbol
    RT1-CE16provided by RGD
    Full Name
    RT1 class I, locus CE16provided by RGD
    Primary source
    RGD:1359403
    See related
    Ensembl:ENSRNOG00000065254 AllianceGenome:RGD:1359403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RT1-Uc; RT1.Cg; RT1-Uav1; RT1-Ulv1
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3261656..3265548, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3257109..3260747, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene transcription factor 19 Neighboring gene POU class 5 homeobox 1 Neighboring gene uncharacterized LOC108353253 Neighboring gene Cdk2ap1-ps8 pseudogene Neighboring gene RT1 class I, locus CE15 Neighboring gene uncharacterized LOC120098828 Neighboring gene LOC224733l-9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequences of three distinct cDNA clones coding for the rat class I heavy chain RT1n antigen. Wang M, et al. Immunogenetics, 1996. PMID 8881041
    2. Characterization of two class I major histocompatibility rat cDNA clones, one of which contains a premature termination codon. Kastern W. Gene, 1985. PMID 3839199
    3. Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats. Dai KZ, et al. J Immunol, 2018 Apr 15. PMID 29531166, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CD8 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD8-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD8-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of memory T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RT1 class I, locus CE16
    Names
    MHC class Ib alpha chain
    MHC class Ib molecule
    MHC class Ib, RT1-Uav1
    MHC class Ib, RT1-Uc
    MHC class Ib, RT1-Ulv1
    RT1 class I histocompatibility antigen, AA alpha chain-like
    RT1 class I, CE16 precursor, RT1-Un
    class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like
    mature MHC class I alpha heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008839.2 → NP_001008839.1  RT1 class I, locus CE16 precursor

      See identical proteins and their annotated locations for NP_001008839.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A2P1NRY6, P79589, Q6MG28
      Related
      ENSRNOP00000057699.5, ENSRNOT00000060980.4
      Conserved Domains (2) summary
      cd07698
      Location:207 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:25 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3261656..3265548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279421.1 → XP_063135491.1  RT1 class I, locus CE16 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YPS9

    2. XM_063279422.1 → XP_063135492.1  RT1 class I, locus CE16 isoform X2

    3. XM_063279423.1 → XP_063135493.1  RT1 class I, locus CE16 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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