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    Ralgapb Ral GTPase activating protein non-catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362257, updated on 6-Jun-2024

    Summary

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    Symbol
    Ralgapbprovided by RGD
    Full Name
    Ral GTPase activating protein non-catalytic subunit betaprovided by RGD
    Primary source
    RGD:1306861
    See related
    Ensembl:ENSRNOG00000014836 AllianceGenome:RGD:1306861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p170; RGD1306861
    Summary
    Enables GTPase activator activity and protein heterodimerization activity. Involved in activation of GTPase activity. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 234.4), Kidney (RPKM 206.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ralgapb in Genome Data Viewer
    Location:
    3q42
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167482344..167571975)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147062443..147152090)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (154910291..154983021)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 71E Neighboring gene small nucleolar RNA host gene 11 Neighboring gene small nucleolar RNA, H/ACA box 60 Neighboring gene adipogenin Neighboring gene Rho GTPase activating protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. Shirakawa R, et al. J Biol Chem, 2009 Aug 7. PMID 19520869, Free PMC Article
    2. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ral protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of exocyst localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ral GTPase-activating protein subunit beta
    Names
    Ral GTPase activating protein non-catalytic beta subunit
    Ral GTPase activating protein, beta subunit (non-catalytic)
    ral GTPase-activating protein subunit beta-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271210.2 → NP_001258139.1  ral GTPase-activating protein subunit beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P86410

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167482344..167571975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235420.5 → XP_006235482.2  ral GTPase-activating protein subunit beta isoform X3

      UniProtKB/Swiss-Prot
      P86410
      UniProtKB/TrEMBL
      A0A0G2K0K8
      Related
      ENSRNOP00000071487.2

    2. XM_006235416.5 → XP_006235478.2  ral GTPase-activating protein subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P86410
      UniProtKB/TrEMBL
      A0A0G2KA57
      Related
      ENSRNOP00000075270.2

    3. XM_006235418.5 → XP_006235480.2  ral GTPase-activating protein subunit beta isoform X2

      UniProtKB/Swiss-Prot
      P86410

    4. XM_006235421.5 → XP_006235483.2  ral GTPase-activating protein subunit beta isoform X4

      UniProtKB/Swiss-Prot
      P86410

    5. XM_063284185.1 → XP_063140255.1  ral GTPase-activating protein subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P86410
      UniProtKB/TrEMBL
      A0A0G2KA57

    6. XM_063284186.1 → XP_063140256.1  ral GTPase-activating protein subunit beta isoform X5

      UniProtKB/Swiss-Prot
      P86410
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86410.1 GenPept UniProtKB/Swiss-Prot:P86410

    Gene LinkOut

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