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    TMEM33 transmembrane protein 33 [ Homo sapiens (human) ]

    Gene ID: 55161, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TMEM33provided by HGNC
    Official Full Name
    transmembrane protein 33provided by HGNC
    Primary source
    HGNC:HGNC:25541
    See related
    Ensembl:ENSG00000109133 MIM:618515; AllianceGenome:HGNC:25541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Pom33; SHINC3; SHINC-3; 1600019D15Rik
    Summary
    Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41935137..41960803)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41908187..41934614)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41937446..41962820)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41910569-41911460 Neighboring gene uncharacterized LOC105374426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:41914902-41916101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21510 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:41983504-41984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21511 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41992428-41992647 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene solute carrier family 30 member 9 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. Liu F, et al. EMBO J, 2021 Nov 15. PMID 34487377, Free PMC Article
    2. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Sakabe I, et al. Breast Cancer Res Treat, 2015 Sep. PMID 26268696, Free PMC Article
    3. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, et al. Nat Commun, 2019 May 2. PMID 31048699, Free PMC Article
    4. Identification and characterization of TMEM33 as a reticulon-binding protein. Urade T, et al. Kobe J Med Sci, 2014 Nov 6. PMID 25612671
    5. Purification and identification of G protein-coupled receptor protein complexes under native conditions. Daulat AM, et al. Mol Cell Proteomics, 2007 May. PMID 17215244

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
      Title: PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
    2. TMEM33 is a novel regulator of the PERK-eIE2alpha-ATF4 and IRE1-XBP1 axes of the UPR signaling.
      Title: TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transmembrane protein 33 (TMEM33) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10525

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of IRE1-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of PERK-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endoplasmic reticulum tubular network organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018126.3 → NP_060596.2  transmembrane protein 33

      See identical proteins and their annotated locations for NP_060596.2

      Status: VALIDATED

      Source sequence(s)
      AC106052, BC000948
      Consensus CDS
      CCDS3464.1
      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953
      UniProtKB/TrEMBL
      A6QKW0
      Related
      ENSP00000422473.1, ENST00000504986.6
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      41935137..41960803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248116.5 → XP_005248173.1  transmembrane protein 33 isoform X1

      See identical proteins and their annotated locations for XP_005248173.1

      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953
      UniProtKB/TrEMBL
      A6QKW0
      Related
      ENSP00000422810.1, ENST00000508448.5
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    2. XM_005248117.3 → XP_005248174.1  transmembrane protein 33 isoform X1

      See identical proteins and their annotated locations for XP_005248174.1

      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953
      UniProtKB/TrEMBL
      A6QKW0
      Related
      ENSP00000427006.1, ENST00000513702.5
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      41908187..41934614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350372.1 → XP_054206347.1  transmembrane protein 33 isoform X1

      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953

    2. XM_054350370.1 → XP_054206345.1  transmembrane protein 33 isoform X1

      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953

    3. XM_054350371.1 → XP_054206346.1  transmembrane protein 33 isoform X1

      UniProtKB/Swiss-Prot
      B3KSS8, P57088, Q9H953
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57088.2 GenPept UniProtKB/Swiss-Prot:P57088

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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