PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PIK3R1provided by VGNC
Official Full Name: phosphoinositide-3-kinase regulatory subunit 1provided by VGNC
Primary source: VGNC:VGNC:75999
See related: Ensembl:ENSMMUG00000011532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	6	NC_041759.1 (66749717..66835246)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	6	NC_027898.1 (66351488..66437539)

Chromosome 6 - NC_041759.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH44517 (e-PCR)
- UniSTS:23069

WI-16112 (e-PCR)
- UniSTS:32034

RH17716 (e-PCR)
- UniSTS:69667

PMC291832P1 (e-PCR)
- UniSTS:272438

PMC291832P2 (e-PCR)
- UniSTS:272439

RH123681 (e-PCR)
- UniSTS:135235

SHGC-36976 (e-PCR)
- UniSTS:5993

PIK3R1_8543 (e-PCR)
- UniSTS:467832

RH75365 (e-PCR)
- UniSTS:84394

SHGC-107225 (e-PCR)
- UniSTS:183999

SHGC-36907 (e-PCR)
- UniSTS:23772

GDB:631841 (e-PCR)
- UniSTS:158435

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit alpha

Names: phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001261197.1 → NP_001248126.1 phosphatidylinositol 3-kinase regulatory subunit alpha

See identical proteins and their annotated locations for NP_001248126.1

Status: PROVISIONAL

Source sequence(s)

JV047385

UniProtKB/TrEMBL

G7MU74, H9ZA51

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041759.1 Reference Mmul_10 Primary Assembly

Range

66749717..66835246

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015140166.2 → XP_014995652.2 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

UniProtKB/TrEMBL

F7BZL6, G7MU74

Related

ENSMMUP00000015140.3, ENSMMUT00000016153.4

Conserved Domains (5) summary

cd09930
Location:617 → 720

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:325 → 435

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11910
Location:5 → 79

SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12924
Location:440 → 600

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:114 → 302

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...
XM_015140167.2 → XP_014995653.2 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

Conserved Domains (4) summary

cd09930
Location:442 → 545

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:150 → 260

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:265 → 425

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

cd04388
Location:1 → 127

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...
XM_015140169.2 → XP_014995655.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

UniProtKB/TrEMBL

F7BZL0, F7GX86

Related

ENSMMUP00000034576.3, ENSMMUT00000041550.3

Conserved Domains (3) summary

cd09930
Location:317 → 420

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:25 → 135

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:140 → 300

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
XM_015140168.2 → XP_014995654.1 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

UniProtKB/TrEMBL

F7BZK1, H9FVU7

Related

ENSMMUP00000015142.4, ENSMMUT00000016155.4

Conserved Domains (3) summary

cd09930
Location:347 → 450

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:55 → 165

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12924
Location:170 → 330

iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha