Abcb11 ATP binding cassette subfamily B member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb11provided by RGD
Official Full Name: ATP binding cassette subfamily B member 11provided by RGD
Primary source: RGD:619930
See related: Ensembl:ENSRNOG00000050860 AllianceGenome:RGD:619930
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bsep; Spgp
Summary: Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; response to 17alpha-ethynylestradiol; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1400.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (74424620..74520646, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (54016854..54112797, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (55480024..55587946, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicininduced liver injury in rats.
Title: Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats.
In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver.
Title: Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.
bile acid homeostasis in rats was regulated through bile acid synthesis and transport in response to Bsep deficiency and roglitazone inhibition
Title: Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.
Calculus Bovis administration can alleviate liver injury and up-regulate the expression of BSEP and MRP2 in 17alpha-ethynylestradiol-induced cholestasis by a mechanism that may involve inhibiting the activated PI3K/Akt signaling pathway.
Title: Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17α-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway.
results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions
Title: Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
The pericentral downregulation of Bsep and Mrp2 following cold I/R is ameliorated by inducing HO-1 and was associated with diminished hepatocellular JNK and Fyn signaling.
Title: HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion.
Ginsenoside promotion of hepatic cholesterol metabolism does not involve effects on BSEP.
Title: Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism.
FXR regulates BSEP in an isoform-dependent and species-specific manner
Title: Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor.
show that AP2 interacts with BSEP at the canalicular membrane through a tyrosine motif at the carboxyl terminus of BSEP
Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.
hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation.
Title: The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type bile acid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type bile acid transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type bile acid transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type bile acid transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type bile acid transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables bile acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables canalicular bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables canalicular bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables canalicular bile acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables canalicular bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid and bile salt transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid and bile salt transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in canalicular bile acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in canalicular bile acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in canalicular bile acid transport	IEA Inferred from Electronic Annotation more info
involved_in canalicular bile acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canalicular bile acid transport	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bile acid secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bile acid secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bile acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of bile acid secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic export from cell	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic export from cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic export from cell	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic export from cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
NOT located_in basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular canaliculus	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in intracellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular canaliculus	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: bile salt export pump

Names: ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; sister of P-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031760.1 → NP_113948.1 bile salt export pump

See identical proteins and their annotated locations for NP_113948.1

Status: PROVISIONAL

Source sequence(s)

U69487

UniProtKB/Swiss-Prot

O70127

UniProtKB/TrEMBL

A0A2P1EA62, M0R4J2, O88331

Related

ENSRNOP00000064279.3, ENSRNOT00000075107.3

Conserved Domains (1) summary

PTZ00265
Location:150 → 1314

PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

74424620..74520646 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105931.2 → XP_038961859.1 bile salt export pump isoform X1

UniProtKB/Swiss-Prot

O70127

UniProtKB/TrEMBL

A0A2P1EA62, M0R4J2, O88331

Conserved Domains (1) summary

PTZ00265
Location:150 → 1314

PTZ00265; multidrug resistance protein (mdr1); Provisional
XM_039105932.2 → XP_038961860.1 bile salt export pump isoform X1

UniProtKB/Swiss-Prot

O70127

UniProtKB/TrEMBL

A0A2P1EA62, M0R4J2, O88331

Conserved Domains (1) summary

PTZ00265
Location:150 → 1314

PTZ00265; multidrug resistance protein (mdr1); Provisional
XM_039105933.2 → XP_038961861.1 bile salt export pump isoform X2

UniProtKB/TrEMBL

A0A8I5ZYZ3

Conserved Domains (1) summary

PTZ00265
Location:43 → 1207

PTZ00265; multidrug resistance protein (mdr1); Provisional