Ninj1 ninjurin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ninj1provided by RGD
Official Full Name: ninjurin 1provided by RGD
Primary source: RGD:3179
See related: Ensembl:ENSRNOG00000016587 AllianceGenome:RGD:3179
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cell adhesion mediator activity. Involved in cell adhesion and positive regulation of angiogenesis. Predicted to be located in filopodium membrane and synaptic membrane. Predicted to be integral component of plasma membrane. Predicted to be active in extracellular region. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 300.4), Kidney (RPKM 257.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (15659208..15668115, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (15452804..15461684, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (15866235..15881284, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ninj1 may mediate the entry of myeloid cells into the CNS in normal and EAE brains, and it is a potential therapeutic target for regulating myeloid cell trafficking across the blood-brain barrier in CNS immune processes.
Title: Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables membrane destabilizing activity	ISO Inferred from Sequence Orthology more info
enables membrane destabilizing activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hyaloid vascular plexus regression	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pericyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ninjurin-1

Names: nerve injury-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012867.2 → NP_036999.1 ninjurin-1

See identical proteins and their annotated locations for NP_036999.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P70617

UniProtKB/TrEMBL

A6J6X6, A6J6X8

Related

ENSRNOP00000022341.1, ENSRNOT00000022341.5

Conserved Domains (1) summary

pfam04923
Location:39 → 139

Ninjurin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

15659208..15668115 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276077.1 → XP_063132147.1 ninjurin-1 isoform X1

UniProtKB/Swiss-Prot

P70617

UniProtKB/TrEMBL

A6J6X6
XM_063276078.1 → XP_063132148.1 ninjurin-1 isoform X2

UniProtKB/TrEMBL

A6J6X9