Plpp7 phospholipid phosphatase 7 (inactive) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plpp7provided by RGD
Official Full Name: phospholipid phosphatase 7 (inactive)provided by RGD
Primary source: RGD:1305821
See related: Ensembl:ENSRNOG00000010068 AllianceGenome:RGD:1305821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppapdc3; RGD1305821
Summary: Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane and nuclear envelope. Orthologous to human PLPP7 (phospholipid phosphatase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 556.9), Heart (RPKM 157.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35782215..35796577)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15384461..15398820)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11114551..11130427)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables lipid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive phospholipid phosphatase 7

Names: phosphatidic acid phosphatase type 2 domain containing 3; phosphatidic acid phosphatase type 2 domain-containing protein 3; probable lipid phosphate phosphatase PPAPDC3

NP_001012349.1

EC 3.1.3.-

XP_038960681.1

EC 3.1.3.-

XP_063139561.1

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012349.2 → NP_001012349.1 inactive phospholipid phosphatase 7

See identical proteins and their annotated locations for NP_001012349.1

Status: VALIDATED

Source sequence(s)

AA900756, BC089948, CB771354

UniProtKB/Swiss-Prot

Q5FVJ3

UniProtKB/TrEMBL

A6JU41

Related

ENSRNOP00000013507.4, ENSRNOT00000013507.5

Conserved Domains (2) summary

COG0671
Location:123 → 249

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03391
Location:97 → 255

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

35782215..35796577

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104753.2 → XP_038960681.1 inactive phospholipid phosphatase 7 isoform X1

Conserved Domains (1) summary

cd03391
Location:39 → 143

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...
XM_063283491.1 → XP_063139561.1 inactive phospholipid phosphatase 7 isoform X2

UniProtKB/TrEMBL

A0A8I6AEA9