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    St6galnac6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407765, updated on 13-Apr-2024

    Summary

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    Official Symbol
    St6galnac6provided by RGD
    Official Full Name
    ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6provided by RGD
    Primary source
    RGD:1303196
    See related
    Ensembl:ENSRNOG00000046984 AllianceGenome:RGD:1303196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat7F
    Summary
    Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ceramide metabolic process; glycoprotein metabolic process; and oligosaccharide biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 118.8), Muscle (RPKM 92.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36283573..36305217)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15894275..15907502)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11620050..11641460)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene adenylate kinase 1 Neighboring gene endoglin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Senda M, et al. Biochem J, 2007 Mar 15. PMID 17123352, Free PMC Article
    2. Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene. Okajima T, et al. J Biol Chem, 2000 Mar 10. PMID 10702226
    3. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
    4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109387

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    Names
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
    ST6 GalNAc alpha-2,6-sialyltransferase 6
    alpha-2,6-sialyltransferase ST6GalNAc VI
    sialyltransferase 7F
    NP_001385873.1
    XP_038961570.1
    XP_063140387.1
    XP_063140388.1
    XP_063140389.1
    XP_063140390.1
    XP_063140391.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398944.1 → NP_001385873.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU71, M0R3S4
      Related
      ENSRNOP00000063995.3, ENSRNOT00000074401.3
      Conserved Domains (1) summary
      pfam00777
      Location:102 → 287
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36283573..36305217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284319.1 → XP_063140389.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

    2. XM_063284318.1 → XP_063140388.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X2

    3. XM_039105642.2 → XP_038961570.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:1 → 133
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_063284317.1 → XP_063140387.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X1

    5. XM_063284321.1 → XP_063140391.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X6

      UniProtKB/TrEMBL
      Q5BJS3

    6. XM_063284320.1 → XP_063140390.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X4

      UniProtKB/TrEMBL
      Q6ZXY0

    RNA

    1. XR_005501955.2 RNA Sequence

    2. XR_005501954.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001015036.1: Suppressed sequence

      Description
      NM_001015036.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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