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    Ppcdc phosphopantothenoylcysteine decarboxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363069, updated on 24-Apr-2024

    Summary

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    Symbol
    Ppcdcprovided by RGD
    Full Name
    phosphopantothenoylcysteine decarboxylaseprovided by RGD
    Primary source
    RGD:1306267
    See related
    Ensembl:ENSRNOG00000018711 Ensembl:ENSRNOG00000053404 AllianceGenome:RGD:1306267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306267
    Summary
    Predicted to enable FMN binding activity; identical protein binding activity; and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 16.4), Kidney (RPKM 15.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppcdc in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66711115..66738782, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57815195..57842863, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62191722..62219434, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 15 open reading frame 39 Neighboring gene uncharacterized LOC134479975 Neighboring gene secretory carrier membrane protein 5 Neighboring gene ribonuclease P and MRP subunit p25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Abrie JA, et al. Sci Rep, 2015 Oct 30. PMID 26514574, Free PMC Article
    2. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopantothenoylcysteine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantothenoylcysteine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphopantothenoylcysteine decarboxylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphopantothenoylcysteine decarboxylase
    NP_001102233.1
    XP_008764525.2
    XP_008764526.1
    XP_008764528.1
    XP_008764530.2
    XP_017451225.1
    XP_038937668.1
    XP_063121826.1
    XP_063121827.1
    XP_063121828.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108763.2 → NP_001102233.1  phosphopantothenoylcysteine decarboxylase isoform 1

      See identical proteins and their annotated locations for NP_001102233.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2KAU5, A6J4U8
      Related
      ENSRNOP00000075531.1, ENSRNOT00000080448.2
      Conserved Domains (1) summary
      cl19190
      Location:40 → 230
      Flavoprotein; Flavoprotein

    2. NM_001429413.1 → NP_001416342.1  phosphopantothenoylcysteine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_001429414.1 → NP_001416343.1  phosphopantothenoylcysteine decarboxylase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_001429415.1 → NP_001416344.1  phosphopantothenoylcysteine decarboxylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001429416.1 → NP_001416345.1  phosphopantothenoylcysteine decarboxylase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001429417.1 → NP_001416346.1  phosphopantothenoylcysteine decarboxylase isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66711115..66738782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081740.2 → XP_038937668.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:34 → 129
      Flavoprotein

    2. XM_008766308.4 → XP_008764530.2  phosphopantothenoylcysteine decarboxylase isoform X3

      Conserved Domains (1) summary
      cl19190
      Location:2 → 160
      Flavoprotein

    3. XM_008766303.4 → XP_008764525.2  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/TrEMBL
      A6J4U9, D3ZZZ5
      Conserved Domains (1) summary
      cl19190
      Location:2 → 192
      Flavoprotein

    4. XM_008766306.4 → XP_008764528.1  phosphopantothenoylcysteine decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAU5, A6J4U8
      Conserved Domains (1) summary
      cl19190
      Location:40 → 230
      Flavoprotein; Flavoprotein

    5. XM_063265756.1 → XP_063121826.1  phosphopantothenoylcysteine decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAU5, A6J4U8

    6. XM_008766304.4 → XP_008764526.1  phosphopantothenoylcysteine decarboxylase isoform X2

      See identical proteins and their annotated locations for XP_008764526.1

      UniProtKB/TrEMBL
      A0A0G2KAU5, A6J4U8
      Conserved Domains (1) summary
      cl19190
      Location:40 → 230
      Flavoprotein; Flavoprotein

    7. XM_017595736.3 → XP_017451225.1  phosphopantothenoylcysteine decarboxylase isoform X6

    8. XM_063265757.1 → XP_063121827.1  phosphopantothenoylcysteine decarboxylase isoform X4

    9. XM_063265758.1 → XP_063121828.1  phosphopantothenoylcysteine decarboxylase isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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