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    Dennd2b DENN domain containing 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308944, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dennd2bprovided by RGD
    Official Full Name
    DENN domain containing 2Bprovided by RGD
    Primary source
    RGD:1308995
    See related
    Ensembl:ENSRNOG00000013934 AllianceGenome:RGD:1308995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    St5
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 125.2), Heart (RPKM 85.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd2b in Genome Data Viewer
    Location:
    1q33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172978895..173129623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163544075..163734736, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174137120..174290533, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene uncharacterized LOC134483772 Neighboring gene charged multivesicular body protein 1b-like Neighboring gene similar to human chromosome 11 open reading frame 16 Neighboring gene A-kinase interacting protein 1 Neighboring gene achaete-scute family bHLH transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. Majidi M, et al. J Biol Chem, 1998 Jun 26. PMID 9632734
    2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2B
    Names
    suppression of tumorigenicity 5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395094.1 → NP_001382023.1  DENN domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AKA1
      Related
      ENSRNOP00000089151.1, ENSRNOT00000099927.1
      Conserved Domains (3) summary
      smart00801
      Location:1020 → 1086
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 969
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      172978895..173129623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263096.1 → XP_063119166.1  DENN domain-containing protein 2B isoform X3

    2. XM_063263081.1 → XP_063119151.1  DENN domain-containing protein 2B isoform X1

    3. XM_039078198.2 → XP_038934126.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    4. XM_063263101.1 → XP_063119171.1  DENN domain-containing protein 2B isoform X6

    5. XM_063263099.1 → XP_063119169.1  DENN domain-containing protein 2B isoform X5

    6. XM_039078202.2 → XP_038934130.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    7. XM_039078204.2 → XP_038934132.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Related
      ENSRNOP00000061141.1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    8. XM_039078205.2 → XP_038934133.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    9. XM_039078206.2 → XP_038934134.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    10. XM_039078199.2 → XP_038934127.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    11. XM_039078207.2 → XP_038934135.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    12. XM_039078194.2 → XP_038934122.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    13. XM_039078208.2 → XP_038934136.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKA1
      Conserved Domains (3) summary
      smart00801
      Location:1039 → 1105
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 988
      DENN; DENN (AEX-3) domain

    14. XM_039078209.2 → XP_038934137.1  DENN domain-containing protein 2B isoform X4

      UniProtKB/TrEMBL
      A0A8I6A484
      Related
      ENSRNOP00000085739.1
      Conserved Domains (3) summary
      smart00801
      Location:1025 → 1091
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:680 → 767
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:774 → 974
      DENN; DENN (AEX-3) domain

    15. XM_039078211.2 → XP_038934139.2  DENN domain-containing protein 2B isoform X7

    16. XM_063263111.1 → XP_063119181.1  DENN domain-containing protein 2B isoform X8

    17. XM_039078212.2 → XP_038934140.1  DENN domain-containing protein 2B isoform X9

      Conserved Domains (1) summary
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107547.1: Suppressed sequence

      Description
      NM_001107547.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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