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    Cks2 CDC28 protein kinase regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498709, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cks2provided by RGD
    Official Full Name
    CDC28 protein kinase regulatory subunit 2provided by RGD
    Primary source
    RGD:1562047
    See related
    AllianceGenome:RGD:1562047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562047
    Summary
    Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within several processes, including meiosis I; mitotic cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CKS2 (CDC28 protein kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 261.6), Testes (RPKM 194.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cks2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (13722360..13727519, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (13570611..13575770, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13587664..13593423, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene semaphorin 4D Neighboring gene uncharacterized LOC134482683 Neighboring gene SECIS binding protein 2 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene SHC adaptor protein 3 Neighboring gene sphingosine-1-phosphate receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Spruck CH, et al. Science, 2003 Apr 25. PMID 12714746
    2. Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Martinsson-Ahlzén HS, et al. Mol Cell Biol, 2008 Sep. PMID 18625720, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinases regulatory subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126083.1 → NP_001119555.1  cyclin-dependent kinases regulatory subunit 2

      See identical proteins and their annotated locations for NP_001119555.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162005
      UniProtKB/TrEMBL
      B1WC51
      Conserved Domains (1) summary
      pfam01111
      Location:8 → 73
      CKS; Cyclin-dependent kinase regulatory subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      13722360..13727519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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