Shtn1 shootin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shtn1provided by RGD
Official Full Name: shootin 1provided by RGD
Primary source: RGD:1311558
See related: Ensembl:ENSRNOG00000018350 AllianceGenome:RGD:1311558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Shootin1; RGD1311558
Summary: Enables actin filament binding activity and cell adhesion molecule binding activity. Involved in several processes, including Cdc42 protein signal transduction; actin filament bundle retrograde transport; and netrin-activated signaling pathway. Acts upstream of or within axonogenesis. Located in axonal growth cone; filopodium; and lamellipodium. Orthologous to human SHTN1 (shootin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 127.3), Kidney (RPKM 86.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (268108095..268211947, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (258121966..258225861, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (280129228..280233873, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that shootin1b may function in various peripheral tissues including epithelial cells.
Title: Identification of a shootin1 isoform expressed in peripheral tissues.
The shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth.
Title: Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth.
Shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. A chemoattractant, netrin-1, positively regulates traction forces at axonal growth cones via Pak1-mediated shootin1 phosphorylation.
Title: Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation.
Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth
Title: Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth.
Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization.
Title: Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization.

Submit: New GeneRIF Correction

General gene information

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Markers

AU026772 (e-PCR)
- UniSTS:113952

BF399364 (e-PCR)
- UniSTS:247652

RH130905 (e-PCR)
- UniSTS:214189

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament bundle retrograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic actin-based contraction involved in cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum polarization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum polarization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum polarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in netrin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration, cell extension	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in cell leading edge	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: shootin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079705.4 → NP_001073173.2 shootin-1 isoform 1

See identical proteins and their annotated locations for NP_001073173.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as shootin 1b).

Source sequence(s)

BC085922, CO392889, JAXUCZ010000001

UniProtKB/Swiss-Prot

A0MZ64, A0MZ67

UniProtKB/TrEMBL

A0A8I6AFL7, A6JI78

Related

ENSRNOP00000061843.4, ENSRNOT00000064463.4

Conserved Domains (2) summary

pfam10267
Location:268 → 350

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

pfam10493
Location:215 → 306

Rod_C; Rough deal protein C-terminal region
NM_001303537.1 → NP_001290466.1 shootin-1 isoform 2

See identical proteins and their annotated locations for NP_001290466.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the 3' coding region, compared to variant 1. This difference results in a shorter isoform (2, also known as shootin 1a) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC085922, CB751427, CO392889, JAXUCZ010000001

UniProtKB/Swiss-Prot

A0MZ67

Related

ENSRNOP00000074944.2, ENSRNOT00000085778.2

Conserved Domains (1) summary

pfam10493
Location:215 → 306

Rod_C; Rough deal protein C-terminal region