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    Tlcd4 TLC domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365924, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tlcd4provided by RGD
    Official Full Name
    TLC domain containing 4provided by RGD
    Primary source
    RGD:1563041
    See related
    Ensembl:ENSRNOG00000025160 AllianceGenome:RGD:1563041
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem56; RGD1563041
    Summary
    Predicted to be involved in lipid homeostasis. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to several human genes including TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 162.6), Muscle (RPKM 162.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tlcd4 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (211969612..212044883, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209284873..209360156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224768034..224843198, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RWD domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ALG14, UDP-N-acetylglucosaminyltransferase subunit Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene uncharacterized LOC120100935

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TLC domain-containing protein 4
    Names
    transmembrane protein 56

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135879.1 → NP_001129351.1  TLC domain-containing protein 4

      See identical proteins and their annotated locations for NP_001129351.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      211969612..212044883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233252.5 → XP_006233314.1  TLC domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233314.1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    2. XM_039102803.2 → XP_038958731.1  TLC domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    3. XM_006233251.5 → XP_006233313.1  TLC domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233313.1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    4. XM_039102801.2 → XP_038958729.1  TLC domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    5. XM_063282296.1 → XP_063138366.1  TLC domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4AAE5

    6. XM_006233246.5 → XP_006233308.1  TLC domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233308.1

      UniProtKB/TrEMBL
      D4AAE5
      Related
      ENSRNOP00000033667.3
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    7. XM_006233244.5 → XP_006233306.1  TLC domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233306.1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    8. XM_006233253.5 → XP_006233315.1  TLC domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233315.1

      UniProtKB/TrEMBL
      D4AAE5
      Conserved Domains (1) summary
      smart00724
      Location:45 → 246
      TLC; TRAM, LAG1 and CLN8 homology domains

    9. XM_063282294.1 → XP_063138364.1  TLC domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4AAE5

    10. XM_063282295.1 → XP_063138365.1  TLC domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4AAE5
    Nucleotide Protein Strain
    Heading Accession and Version

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