Hpd 4-hydroxyphenylpyruvate dioxygenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpdprovided by RGD
Official Full Name: 4-hydroxyphenylpyruvate dioxygenaseprovided by RGD
Primary source: RGD:61974
See related: Ensembl:ENSRNOG00000001338 AllianceGenome:RGD:61974
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 4-hydroxyphenylpyruvate dioxygenase activity. Involved in tyrosine catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 8012.7) and Kidney (RPKM 4514.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (39042246..39053596)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (33381397..33392750)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38828606..38839956)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report utility of HPD for monitoring drug-induced liver injury in rat model.
Title: A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
Mutation in the rat (N241S) 4-hydroxyphenylpyruvate dioxygenase genes shows that the variant enzyme forms quinolacetic acid in place of the native product 2,5-dihydroxyphenylacetic acid.
Title: Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria.

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General gene information

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Markers

GDB:455130 (e-PCR)
- UniSTS:157452

RH141029 (e-PCR)
- UniSTS:223029

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxyphenylpyruvate dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 4-hydroxyphenylpyruvate dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxyphenylpyruvate dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables 4-hydroxyphenylpyruvate dioxygenase activity	TAS Traceable Author Statement more info	PubMed
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tyrosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tyrosine catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 4-hydroxyphenylpyruvate dioxygenase

Names: 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPPDase; f Alloantigen; f protein

NP_058929.1

EC 1.13.11.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.