Wnt7b wingless-type MMTV integration site family, member 7B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt7bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 7Bprovided by MGI
Primary source: MGI:MGI:98962
See related: Ensembl:ENSMUSG00000022382 AllianceGenome:MGI:98962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt-7b
Summary: Enables chemoattractant activity involved in axon guidance and frizzled binding activity. Involved in nervous system development and stem cell development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and oxygen homeostasis. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 14.2), CNS E14 (RPKM 11.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 40.39 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (85419638..85466022, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (85535437..85581821, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt7b expressed by hypertrophic chondrocytes is a stimulatory factor for endochondral ossification that is regulated by Smad4 activity.
Title: Wnt7b expressed by hypertrophic chondrocytes is a stimulatory factor for endochondral ossification that is regulated by Smad4 activity.
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Title: The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells.
Title: Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells.
Compound transgenic mice overexpress Wnt7b transiently in the osteoblast lineage of postnatal mice, with or without concurrent deletion of Glut1. Wnt7b overexpression stimulated bone formation, but this was abolished without Glut1. Wnt7b increased Glut1 expression and glucose consumption in the primary cultured osteoblast lineage cells. Wnt7b promotes bone formation in part through stimulating glucose metabolism in them.
Title: Increased glycolysis mediates Wnt7b-induced bone formation.
Our results suggest that aberrant Wnt7b expression activated c-jun N-terminal kinase (JNK), which down-regulated mitochondria numbers by suppressing Ppargc1a Down-regulation of Ppargc1a probably decreased reactive oxygen species and enhanced glycolysis
Title: Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
Wnt7b enhances dentinogenesis by increasing the proliferation and differentiation of dental mesenchymal cells partly through ERK1/2 pathway
Title: The role of Wnt7B in the mediation of dentinogenesis via the ERK1/2 pathway.
Wnt7b and Fz7 induce the phosphorylation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and JNK proteins, which are required for dendritic development.
Title: Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK.
Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410.
Title: Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410.
experiments define the extent of CNS region-specific cooperation for several components of the Norrin and Wnt7a/Wnt7b systems, and they reveal substantial regional heterogeneity in the extent to which partially redundant ligands, receptors, and coactivators maintain the blood-brain barrier and blood-retina barrier
Title: Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.
Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation.
Title: Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt7b (e-PCR), detects polymorphism
- UniSTS:508424

Wnt7b (e-PCR), detects polymorphism
- UniSTS:465426

Wnt7b (e-PCR), detects polymorphism
- UniSTS:526102

Wnt7b (e-PCR), detects polymorphism
- UniSTS:471330

Wnt7b (e-PCR), detects polymorphism
- UniSTS:527144

Wnt7b (e-PCR), detects polymorphism
- UniSTS:277888

Wnt7b (e-PCR), detects polymorphism
- UniSTS:144785

Wnt7b (e-PCR), detects polymorphism
- UniSTS:507324

M89802 (e-PCR)
- UniSTS:160492

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IC Inferred by Curator more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anatomical structure regression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation in forebrain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemoattraction of dopaminergic neuron axon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chorio-allantoic fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic placenta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain regionalization	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within homeostatic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner medullary collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular oxygen homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lobar bronchus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung-associated mesenchyme development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric loop of Henle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within outer medullary collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell projection size	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal inner medulla development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal outer medulla development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trachea cartilage morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-7b

Names: wingless-related MMTV integration site 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163633.1 → NP_001157105.1 protein Wnt-7b isoform 3

See identical proteins and their annotated locations for NP_001157105.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1, and initiates translation from an in-frame downstream AUG, resulting in a shorter isoform (3) compared to isoform 1.

Source sequence(s)

AC162302, AK087499, BC052018, BQ032129

Consensus CDS

CCDS49691.1

UniProtKB/TrEMBL

E9Q5E3

Related

ENSMUSP00000130627.2, ENSMUST00000167968.9

Conserved Domains (1) summary

cl38924
Location:1 → 282

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
NM_001163634.1 → NP_001157106.1 protein Wnt-7b isoform 2

See identical proteins and their annotated locations for NP_001157106.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1, and encodes a slightly longer isoform (2) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

BC052018, BC066003, BQ032129

Consensus CDS

CCDS49692.1

UniProtKB/TrEMBL

Q6NZR1

Related

ENSMUSP00000155014.2, ENSMUST00000229191.2

Conserved Domains (1) summary

cd19350
Location:36 → 353

wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins
NM_009528.3 → NP_033554.3 protein Wnt-7b isoform 1 precursor

See identical proteins and their annotated locations for NP_033554.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

BC052018, BC058398, BQ032129

Consensus CDS

CCDS37171.1

UniProtKB/Swiss-Prot

P28047, Q80US5

Related

ENSMUSP00000105051.4, ENSMUST00000109424.4

Conserved Domains (1) summary

cd19350
Location:32 → 349

wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins