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    Tmem106c transmembrane protein 106C [ Mus musculus (house mouse) ]

    Gene ID: 380967, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem106cprovided by MGI
    Official Full Name
    transmembrane protein 106Cprovided by MGI
    Primary source
    MGI:MGI:1196384
    See related
    Ensembl:ENSMUSG00000052369 AllianceGenome:MGI:1196384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Ertd405e
    Summary
    Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain and retina. Orthologous to human TMEM106C (transmembrane protein 106C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 24.2), bladder adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F1; 15 53.96 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97862077..97868158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97963177..97970286)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33690 Neighboring gene STARR-seq mESC enhancer starr_39643 Neighboring gene vitamin D (1,25-dihydroxyvitamin D3) receptor Neighboring gene predicted gene, 52171 Neighboring gene STARR-positive B cell enhancer mm9_chr15:97738623-97738923 Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536 Neighboring gene predicted gene, 41395

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC54819

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 106C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252153.2 → NP_001239082.1  transmembrane protein 106C isoform 1

      See identical proteins and their annotated locations for NP_001239082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS27785.1
      UniProtKB/Swiss-Prot
      Q80VP8
      Related
      ENSMUSP00000154819.2, ENSMUST00000229428.2
      Conserved Domains (1) summary
      pfam07092
      Location:18 → 246
      DUF1356; Protein of unknown function (DUF1356)

    2. NM_001356508.2 → NP_001343437.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS27785.1
      UniProtKB/Swiss-Prot
      Q80VP8
      Conserved Domains (1) summary
      pfam07092
      Location:18 → 246
      DUF1356; Protein of unknown function (DUF1356)

    3. NM_001416066.1 → NP_001402995.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/Swiss-Prot
      Q80VP8

    4. NM_001416067.1 → NP_001402996.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/Swiss-Prot
      Q80VP8

    5. NM_001416068.1 → NP_001402997.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/Swiss-Prot
      Q80VP8

    6. NM_001416069.1 → NP_001402998.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/Swiss-Prot
      Q80VP8

    7. NM_001416070.1 → NP_001402999.1  transmembrane protein 106C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/Swiss-Prot
      Q80VP8

    8. NM_001416071.1 → NP_001403000.1  transmembrane protein 106C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158787

    9. NM_001416072.1 → NP_001403001.1  transmembrane protein 106C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158787

    10. NM_001416073.1 → NP_001403002.1  transmembrane protein 106C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158787

    11. NM_001416074.1 → NP_001403003.1  transmembrane protein 106C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158787

    12. NM_201359.3 → NP_958747.1  transmembrane protein 106C isoform 1

      See identical proteins and their annotated locations for NP_958747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS27785.1
      UniProtKB/Swiss-Prot
      Q80VP8
      Related
      ENSMUSP00000069764.8, ENSMUST00000064200.9
      Conserved Domains (1) summary
      pfam07092
      Location:18 → 246
      DUF1356; Protein of unknown function (DUF1356)

    RNA

    1. NR_183250.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158787

    2. NR_183251.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158787

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97862077..97868158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521120.3 → XP_006521183.1  transmembrane protein 106C isoform X1

      See identical proteins and their annotated locations for XP_006521183.1

      UniProtKB/Swiss-Prot
      Q80VP8
      Conserved Domains (1) summary
      pfam07092
      Location:18 → 246
      DUF1356; Protein of unknown function (DUF1356)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VP8.1 GenPept UniProtKB/Swiss-Prot:Q80VP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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