MOV10 Mov10 RNA helicase [Homo sapiens (human)] - Gene

Summary

Official Symbol: MOV10provided by HGNC
Official Full Name: Mov10 RNA helicaseprovided by HGNC
Primary source: HGNC:HGNC:7200
See related: Ensembl:ENSG00000155363 MIM:610742; AllianceGenome:HGNC:7200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: gb110; fSAP113
Summary: Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (112674439..112700739)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (112687020..112713316)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (113217061..113243361)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties.
Title: MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties.
Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.
Title: Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.
The association of MOV10 polymorphism and expression levels with preeclampsia in the Chinese Han population.
Title: The association of MOV10 polymorphism and expression levels with preeclampsia in the Chinese Han population.
CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
Title: CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
MOV10 restricts hepatitis B virus replication by inhibiting viral reverse transcription
Title: The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.
the antiviral activity of MOV10 is partially countered by viral NS1 protein that interferes with the interaction of MOV10 with viral NP and causes MOV10 degradation through the lysosomal pathway.
Title: MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.
MOV10 interacts with RNASEH2, and their interplay is crucial for restricting L1 retrotransposition.
Title: Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition.
MOV10 / circ-DICER1 / miR-103a-3p (miR-382-5p) / ZIC4 pathway plays a vital role in regulating the angiogenesis of glioma.
Title: MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.
Through interference with the ubiquitin-proteasome system, MOV10 enhances the level of apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G in HIV-1-infected cells and virions, and synergistically inhibits the replication and infectivity of HIV-1.
Title: Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway.
these results establish MOV10, an evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I-like receptor-independent pathway to enhance IFN response
Title: MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2019-03-12) ClinGen Genome Curation Page Haploinsufficency No evidence available (Last evaluated 2019-03-12) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells	PubMed
	gag	Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	gag	Overexpression of the Mov10 mutants, G681A/D682A and R730A/N731A, impairs Mov10-mediated decrease of HIV-1 Gag expression in cells and the incorporation efficiency of Mov10 into particles	PubMed
	gag	The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6	PubMed
	gag	Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression	PubMed
	gag	Overexpression of A3G and Mov10 decreases the efficiency of HIV-1 Gag processing in the virus-producing cells	PubMed
	gag	MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag	PubMed
	gag	HIV-1 Gag binds to the N-terminal amino acids 261-305 region of MOV10. The seven helicase motifs of MOV10 are not required for its interaction with Gag, while all but one of them (motif V) are required for MOV10 packaging into virions	PubMed
Rev	rev	HIV-1 Rev requires MOV10 helicase activity for enhanced function	PubMed
	rev	HIV-1 Rev interacts with Rev	PubMed
	rev	Rev/RRE expression is specifically upregulated by MOV10 in a Rev/RRE-dependent reprter gene assay	PubMed
nucleocapsid	gag	MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-146252 (e-PCR)
- UniSTS:175104

D1S2002E (e-PCR)
- UniSTS:151312

SHGC-75344 (e-PCR)
- UniSTS:81625

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 5'-3' RNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrotransposon silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in retrotransposon silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: helicase MOV-10

Names: Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10, homolog; armitage homolog; functional spliceosome-associated protein 113; moloney leukemia virus 10 protein; putative helicase MOV-10

NP_001123551.1

EC 3.6.4.13

NP_001273001.1

EC 3.6.4.13

NP_001308253.1

EC 3.6.4.13

NP_001356436.1

EC 3.6.4.13

NP_001376491.1

EC 3.6.4.13

NP_001376492.1

EC 3.6.4.13

NP_066014.1

EC 3.6.4.13

XP_024302905.1

EC 3.6.4.13

XP_047277027.1

EC 3.6.4.13

XP_047277030.1

EC 3.6.4.13

XP_047277033.1

EC 3.6.4.13

XP_047277036.1

EC 3.6.4.13

XP_047277038.1

EC 3.6.4.13

XP_054192645.1

EC 3.6.4.13

XP_054192646.1

EC 3.6.4.13

XP_054192647.1

EC 3.6.4.13

XP_054192648.1

EC 3.6.4.13

XP_054192649.1

EC 3.6.4.13

XP_054192650.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130079.3 → NP_001123551.1 helicase MOV-10 isoform 1

See identical proteins and their annotated locations for NP_001123551.1

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS853.1

UniProtKB/Swiss-Prot

Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1

UniProtKB/TrEMBL

B7Z700

Conserved Domains (2) summary

cd18808
Location:734 → 939

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:498 → 733

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_001286072.2 → NP_001273001.1 helicase MOV-10 isoform 2

See identical proteins and their annotated locations for NP_001273001.1

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS65615.1

UniProtKB/TrEMBL

A0A8I5KZ07, Q5JR04

Related

ENSP00000358658.1, ENST00000369644.5

Conserved Domains (2) summary

cd18808
Location:678 → 883

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:442 → 677

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_001321324.2 → NP_001308253.1 helicase MOV-10 isoform 1

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS853.1

UniProtKB/Swiss-Prot

Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1

UniProtKB/TrEMBL

B7Z700

Related

ENSP00000358659.1, ENST00000369645.6

Conserved Domains (2) summary

cd18808
Location:734 → 939

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:498 → 733

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_001369507.1 → NP_001356436.1 helicase MOV-10 isoform 1

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS853.1

UniProtKB/Swiss-Prot

Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1

UniProtKB/TrEMBL

B7Z700

Related

ENSP00000350028.2, ENST00000357443.2

Conserved Domains (2) summary

cd18808
Location:734 → 939

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:498 → 733

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_001389562.1 → NP_001376491.1 helicase MOV-10 isoform 2

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS65615.1

UniProtKB/TrEMBL

A0A8I5KZ07, Q5JR04

Related

ENSP00000510374.1, ENST00000686097.1

Conserved Domains (2) summary

cd18808
Location:678 → 883

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:442 → 677

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_001389563.1 → NP_001376492.1 helicase MOV-10 isoform 2

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS65615.1

UniProtKB/TrEMBL

A0A8I5KZ07, Q5JR04

Conserved Domains (2) summary

cd18808
Location:678 → 883

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:442 → 677

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
NM_020963.5 → NP_066014.1 helicase MOV-10 isoform 1

See identical proteins and their annotated locations for NP_066014.1

Status: VALIDATED

Source sequence(s)

AL603832

Consensus CDS

CCDS853.1

UniProtKB/Swiss-Prot

Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1

UniProtKB/TrEMBL

B7Z700

Related

ENSP00000399797.2, ENST00000413052.6

Conserved Domains (2) summary

cd18808
Location:734 → 939

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd18038
Location:498 → 733

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

112674439..112700739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421080.1 → XP_047277036.1 helicase MOV-10 isoform X2
XM_047421082.1 → XP_047277038.1 helicase MOV-10 isoform X2
XM_024447137.2 → XP_024302905.1 helicase MOV-10 isoform X3

UniProtKB/TrEMBL

A0A8I5KXC3

Conserved Domains (2) summary

cd18038
Location:498 → 733

DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

pfam13087
Location:698 → 836

AAA_12; AAA domain
XM_047421071.1 → XP_047277027.1 helicase MOV-10 isoform X1

UniProtKB/TrEMBL

Q5JR04
XM_047421077.1 → XP_047277033.1 helicase MOV-10 isoform X1

UniProtKB/TrEMBL

Q5JR04
XM_047421074.1 → XP_047277030.1 helicase MOV-10 isoform X1

UniProtKB/TrEMBL

Q5JR04