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    Mrpl42 mitochondrial ribosomal protein L42 [ Mus musculus (house mouse) ]

    Gene ID: 67270, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mrpl42provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L42provided by MGI
    Primary source
    MGI:MGI:1333774
    See related
    Ensembl:ENSMUSG00000062981 AllianceGenome:MGI:1333774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L31mt; L42mt; S32mt; PTD007; Rpml31; HSPC204; MRP-L31; MRP-L42; MRP-S32; D10Ertd322e; 2700009F22Rik; 2900055D03Rik
    Summary
    Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL42 (mitochondrial ribosomal protein L42). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 174.9), kidney adult (RPKM 65.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C2; 10 49.39 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95316667..95337811, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95480805..95501949, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730420D15 gene Neighboring gene STARR-seq mESC enhancer starr_27635 Neighboring gene STARR-seq mESC enhancer starr_27638 Neighboring gene STARR-seq mESC enhancer starr_27639 Neighboring gene predicted gene 3619 Neighboring gene predicted gene, 46239 Neighboring gene STARR-seq mESC enhancer starr_27642 Neighboring gene ubiquitin-conjugating enzyme E2N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Use of denaturing HPLC to map human and murine genes and to validate single-nucleotide polymorphisms. Schriml LM, et al. Biotechniques, 2000 Apr. PMID 10769753
    2. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
    3. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    4. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Chern T, et al. Nat Commun, 2022 Jan 10. PMID 35013307, Free PMC Article
    5. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL42
    Names
    28S ribosomal protein L42, mitochondrial
    28S ribosomal protein S32, mitochondrial
    39S ribosomal protein L31, mitochondrial
    39S ribosomal protein L42, mitochondrial
    mitochndrial ribosomal protein L42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359476.1 → NP_001346405.1  large ribosomal subunit protein mL42 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AI839395, AK002530, DV050100, DV060222
      Consensus CDS
      CCDS24137.1
      UniProtKB/Swiss-Prot
      Q9CPV3
      Related
      ENSMUSP00000151636.2, ENSMUST00000218893.2
      Conserved Domains (1) summary
      pfam10210
      Location:46 → 142
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    2. NM_001359477.1 → NP_001346406.1  large ribosomal subunit protein mL42 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AI839395, AK002530, AK012227, DV050100, DV060222
      Consensus CDS
      CCDS88076.1
      UniProtKB/TrEMBL
      A0A1W2P6M3, A0A1W2P7E4
      Related
      ENSMUSP00000151315.2, ENSMUST00000217777.2
      Conserved Domains (1) summary
      pfam10210
      Location:46 → 72
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    3. NM_026065.4 → NP_080341.1  large ribosomal subunit protein mL42 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080341.1

      Status: VALIDATED

      Source sequence(s)
      AI839395, AK003427, DV050100, DV060222
      Consensus CDS
      CCDS24137.1
      UniProtKB/Swiss-Prot
      Q9CPV3
      Related
      ENSMUSP00000075226.3, ENSMUST00000075829.3
      Conserved Domains (1) summary
      pfam10210
      Location:46 → 142
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      95316667..95337811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPV3.1 GenPept UniProtKB/Swiss-Prot:Q9CPV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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