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    B3gat1 beta-1,3-glucuronyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117108, updated on 5-Mar-2024

    Summary

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    Official Symbol
    B3gat1provided by RGD
    Official Full Name
    beta-1,3-glucuronyltransferase 1provided by RGD
    Primary source
    RGD:70880
    See related
    Ensembl:ENSRNOG00000007142 AllianceGenome:RGD:70880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnk-1
    Summary
    Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in cellular response to hypoxia. Located in Golgi membrane and endoplasmic reticulum membrane. Biomarker of pulmonary fibrosis. Orthologous to human B3GAT1 (beta-1,3-glucuronyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 99.8), Kidney (RPKM 16.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3gat1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (33362791..33390446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (25087123..25114692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (27777024..27804368)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479971 Neighboring gene uncharacterized LOC120094098 Neighboring gene U7 small nuclear RNA Neighboring gene galactosidase, beta 1-like 2 Neighboring gene galactosidase, beta 1-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosyltransferases and glycosaminoglycans in bleomycin and transforming growth factor-β1-induced pulmonary fibrosis. Venkatesan N, et al. Am J Respir Cell Mol Biol, 2014 Mar. PMID 24127863
    2. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Gogate SS, et al. Arthritis Rheum, 2011 Jul. PMID 21400481, Free PMC Article
    3. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. Hiyama A, et al. J Bone Miner Res, 2010 May. PMID 19961337, Free PMC Article
    4. Mechanism of trifluralin-induced thyroid tumors in rats. Saghir SA, et al. Toxicol Lett, 2008 Jul 30. PMID 18582544
    5. Polysialic acid and HNK-1 are expressed in the adult rat vestibular endorgans. Isawa M, et al. Neuroreport, 2004 Jul 19. PMID 15232286

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. positive expression for Osterix and HNK1 in undifferentiated ectomesenchymal cells in early and late stages
      Title: Temporo-spatial analysis of Osterix, HNK1 and Sox10 during odontogenesis and maxillaries osteogenesis.
    2. increased expression of CS-GAGs and GlcAT-I in fibrotic lungs and fibrotic lung fibroblasts
      Title: Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of β1,3-glucuronosyltransferase I in pulmonary fibrosis.
    3. Results of these studies demonstrate that BMP-2 and TGF-beta regulate GlcAT-1 expression in nucleus pulposus cells through a signaling network comprising MAPK, AP1, Sp1, and TonEBP
      Title: BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs.
    4. TonEBP activation by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
      Title: Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
    5. Trifluralin-induced total hepatic UGT enzymes (2.4-fold) and mRNA expression of selected hepatic UGT isozymes (UGT1A1, 1.4-fold; UGT1A6, 6.4-fold; UGT2B1, 3.7-fold).
      Title: Mechanism of trifluralin-induced thyroid tumors in rats.
    6. These results combined suggest that both PSA and HNK-1 carbohydrate epitopes are synthesized and may have an important role in the adult peripheral vestibular endorgans.
      Title: Polysialic acid and HNK-1 are expressed in the adult rat vestibular endorgans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
    Names
    UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
    glcAT-P
    glcUAT-P
    glucuronosyltransferase P
    NP_446455.1
    XP_006242796.1
    XP_038936638.1
    XP_038936641.1
    XP_063120855.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054003.1 → NP_446455.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

      See identical proteins and their annotated locations for NP_446455.1

      Status: PROVISIONAL

      Source sequence(s)
      D88035
      UniProtKB/Swiss-Prot
      O35789
      Related
      ENSRNOP00000009825.5, ENSRNOT00000009825.6
      Conserved Domains (1) summary
      pfam03360
      Location:118 → 328
      Glyco_transf_43; Glycosyltransferase family 43

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      33362791..33390446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264785.1 → XP_063120855.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X2

    2. XM_039080710.2 → XP_038936638.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A0H2UHF1, O35789
      UniProtKB/TrEMBL
      A6JYC4
      Conserved Domains (1) summary
      pfam03360
      Location:105 → 315
      Glyco_transf_43; Glycosyltransferase family 43

    3. XM_039080713.2 → XP_038936641.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A0H2UHF1, O35789
      UniProtKB/TrEMBL
      A6JYC4
      Conserved Domains (1) summary
      pfam03360
      Location:105 → 315
      Glyco_transf_43; Glycosyltransferase family 43

    4. XM_006242734.5 → XP_006242796.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006242796.1

      UniProtKB/Swiss-Prot
      A0A0H2UHF1, O35789
      UniProtKB/TrEMBL
      A6JYC4
      Conserved Domains (1) summary
      pfam03360
      Location:105 → 315
      Glyco_transf_43; Glycosyltransferase family 43
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35789.2 GenPept UniProtKB/Swiss-Prot:O35789

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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