Prdx5 peroxiredoxin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prdx5provided by RGD
Official Full Name: peroxiredoxin 5provided by RGD
Primary source: RGD:71007
See related: Ensembl:ENSRNOG00000021125 AllianceGenome:RGD:71007
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aoeb166
Summary: Predicted to enable several functions, including RNA polymerase III transcription regulatory region sequence-specific DNA binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and peroxiredoxin activity. Predicted to be involved in several processes, including NADPH oxidation; cell redox homeostasis; and regulation of apoptotic process. Located in mitochondrion and peroxisome. Orthologous to human PRDX5 (peroxiredoxin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1173.7), Liver (RPKM 915.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213529042..213532787, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204099826..204103589, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222164462..222167447, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis.
Title: Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis.
the role of a key metabolic integrator coenzyme A (CoA) in modulating the activity of Prdx5 was investigated.
Title: A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification.
Prdx5 protects TGF-beta induced fibrosis. Prdx5 negatively modulates TGF-beta induced Stat3 activation.
Title: Peroxiredoxin 5 Protects TGF-β Induced Fibrosis by Inhibiting Stat3 Activation in Rat Kidney Interstitial Fibroblast Cells.
IMS-PRDX5 expression also attenuates the increase in cytosolic [Ca(2+)] in PASMCs during hypoxia.
Title: Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling.
Prdx5 overexpression attenuated injury to small-for-size liver transplants and increased survival in recipients.
Title: Comparative proteome profile during the early period of small-for-size liver transplantation in rats revealed the protective role of Prdx5.
An extrinsic supply of recombinant TAT-PRDX5 and -6 proteins is responsible for inhibiting hyperglycemia-induced retinal pericyte apoptosis.
Title: TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127892 (e-PCR)
- UniSTS:211202

RH142172 (e-PCR)
- UniSTS:231423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables peroxynitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	ISO Inferred from Sequence Orthology more info
enables thioredoxin-dependent peroxiredoxin activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in reactive nitrogen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptosis involved in tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxiredoxin-5, mitochondrial

Names: PLP; antioxidant enzyme B166; peroxiredoxin V; peroxisomal antioxidant enzyme; prx-V; thioredoxin peroxidase PMP20; thioredoxin reductase; thioredoxin-dependent peroxiredoxin 5

NP_446062.1

EC 1.11.1.24

XP_038961056.1

EC 1.11.1.24

XP_038961090.1

EC 1.11.1.24

XP_038961139.1

EC 1.11.1.24

XP_038961236.1

EC 1.11.1.24

XP_063144180.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053610.1 → NP_446062.1 peroxiredoxin-5, mitochondrial precursor

See identical proteins and their annotated locations for NP_446062.1

Status: PROVISIONAL

Source sequence(s)

AF110732

UniProtKB/Swiss-Prot

Q68G22, Q9R063

UniProtKB/TrEMBL

A6HZI8

Related

ENSRNOP00000028687.2, ENSRNOT00000028687.4

Conserved Domains (1) summary

cd03013
Location:57 → 211

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213529042..213532787 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105128.2 → XP_038961056.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_039105308.2 → XP_038961236.1 peroxiredoxin-5, mitochondrial isoform X3

Conserved Domains (1) summary

cd03013
Location:2 → 156

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_039105211.2 → XP_038961139.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_039105162.2 → XP_038961090.1 peroxiredoxin-5, mitochondrial isoform X2

Conserved Domains (1) summary

cd03013
Location:6 → 160

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
XM_063288110.1 → XP_063144180.1 peroxiredoxin-5, mitochondrial isoform X1