Lta4h leukotriene A4 hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lta4hprovided by RGD
Official Full Name: leukotriene A4 hydrolaseprovided by RGD
Primary source: RGD:1311333
See related: Ensembl:ENSRNOG00000004494 AllianceGenome:RGD:1311333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables leukotriene-A4 hydrolase activity. Involved in several processes, including leukotriene metabolic process; response to zinc ion; and type I pneumocyte differentiation. Located in cytoplasm and nucleus. Biomarker of adenocarcinoma; asthma; and squamous cell carcinoma. Orthologous to human LTA4H (leukotriene A4 hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 305.3), Spleen (RPKM 214.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (29856846..29888642)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (27969796..28001600)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (34288333..34320243)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gliotoxin suppresses the biosynthesis of the potent neutrophil chemoattractant LTB4 by direct interference with LTA4H thereby impairing neutrophil functions in invasive aspergillosis.
Title: Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B(4) Formation through Inhibition of Leukotriene A(4) Hydrolase.
The involvement of compartmentalized and coupled changes of LTB4 and LTA4H in the resistance and development of arthritis in CIA model was demonstrated for the first time.
Title: The interrelationship between leukotriene B4 and leukotriene-A4-hydrolase in collagen/adjuvant-induced arthritis in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141007 (e-PCR)
- UniSTS:223007

BF395896 (e-PCR)
- UniSTS:245441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables epoxide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables epoxide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables leukotriene-A4 hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-A4 hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene-A4 hydrolase activity	ISO Inferred from Sequence Orthology more info
enables metalloaminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables tripeptide aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in leukotriene biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukotriene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in type I pneumocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukotriene A-4 hydrolase

Names: LTA-4 hydrolase; tripeptide aminopeptidase LTA4H

NP_001025202.1

EC 3.3.2.6

EC 3.4.11.4

XP_063119270.1

EC 3.3.2.6

EC 3.4.11.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.