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    Serpini2 serpin family I member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171149, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Serpini2provided by RGD
    Official Full Name
    serpin family I member 2provided by RGD
    Primary source
    RGD:619897
    See related
    Ensembl:ENSRNOG00000009903 AllianceGenome:RGD:619897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in regulation of cell adhesion. Predicted to be active in extracellular space. Orthologous to human SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 150.9) and Liver (RPKM 57.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serpini2 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (162313325..162342875, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (160014721..160044271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (173640385..173670790, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1, pseudogene 7 Neighboring gene zinc finger, B-box domain containing Neighboring gene uncharacterized LOC120100849 Neighboring gene WD repeat domain 49 Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene programmed cell death 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells. Hill RM, et al. Ann N Y Acad Sci, 2002 Oct. PMID 12438159
    2. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, et al. Cytogenet Cell Genet, 2001. PMID 11306811
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration
      Title: Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serpin I2
    Names
    neuroserpin
    serine (or cysteine) peptidase inhibitor, clade I, member 2
    serpin peptidase inhibitor, clade I (pancpin), member 2
    serpin peptidase inhibitor, clade I, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134409.2 → NP_001127881.1  serpin I2 precursor

      See identical proteins and their annotated locations for NP_001127881.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6J5Q3, G3V7A3
      Related
      ENSRNOP00000013452.4, ENSRNOT00000013452.6
      Conserved Domains (1) summary
      cl00137
      Location:23 → 405
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      162313325..162342875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133612.1: Suppressed sequence

      Description
      NM_133612.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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