Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajb2provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member B2provided by RGD
Primary source: RGD:1591035
See related: Ensembl:ENSRNOG00000019506 AllianceGenome:RGD:1591035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and modification-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of ATPase activity; protein refolding; and regulation of cellular protein metabolic process. Predicted to be located in inclusion body; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Predicted to be intrinsic component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in distal spinal muscular atrophy type 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 177.1), Brain (RPKM 160.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84179702..84187942)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76731060..76739278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82436453..82444669)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143241 (e-PCR)
- UniSTS:232488

RH128799 (e-PCR)
- UniSTS:212107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified protein reader activity	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	ISO Inferred from Sequence Orthology more info
involved_in regulation of chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily B member 2

Names: DnaJ (Hsp40) homolog, subfamily B, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109541.2 → NP_001103011.1 dnaJ homolog subfamily B member 2 isoform 3

See identical proteins and their annotated locations for NP_001103011.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6JW05, A6JW06, D4ABC2

Related

ENSRNOP00000026467.2, ENSRNOT00000026467.5

Conserved Domains (2) summary

COG0484
Location:3 → 92

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 58

DnaJ; DnaJ domain
NM_001399115.1 → NP_001386044.1 dnaJ homolog subfamily B member 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A5U2, A6JW06

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_001399116.1 → NP_001386045.1 dnaJ homolog subfamily B member 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A5U2, A6JW06

Related

ENSRNOP00000086434.1, ENSRNOT00000111890.1

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_001399117.1 → NP_001386046.1 dnaJ homolog subfamily B member 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6JW06, B2RYA8

Related

ENSRNOP00000074369.1, ENSRNOT00000081958.2

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_001399118.1 → NP_001386047.1 dnaJ homolog subfamily B member 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6JW06, B2RYA8

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84179702..84187942

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245280.2 → XP_006245342.1 dnaJ homolog subfamily B member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A3U5, A6JW06

Related

ENSRNOP00000085337.1

Conserved Domains (4) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 66

DnaJ; DnaJ domain

pfam02809
Location:250 → 266

UIM; Ubiquitin interaction motif

pfam10254
Location:260 → 307

Pacs-1; PACS-1 cytosolic sorting protein
XM_006245281.5 → XP_006245343.1 dnaJ homolog subfamily B member 2 isoform X3

UniProtKB/TrEMBL

A6JW06

Conserved Domains (2) summary

COG0484
Location:3 → 92

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 58

DnaJ; DnaJ domain
XM_063267756.1 → XP_063123826.1 dnaJ homolog subfamily B member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A3U5, A6JW06
XM_039084218.1 → XP_038940146.1 dnaJ homolog subfamily B member 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZJ88, A6JW06

Related

ENSRNOP00000076642.1, ENSRNOT00000098165.1

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
XM_006245279.5 → XP_006245341.1 dnaJ homolog subfamily B member 2 isoform X1

See identical proteins and their annotated locations for XP_006245341.1

UniProtKB/TrEMBL

A0A8I6A5U2, A6JW06

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
XM_063267759.1 → XP_063123829.1 dnaJ homolog subfamily B member 2 isoform X6

UniProtKB/TrEMBL

A6JW06, B2RYA8
XM_063267755.1 → XP_063123825.1 dnaJ homolog subfamily B member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A3U5, A6JW06
XM_063267758.1 → XP_063123828.1 dnaJ homolog subfamily B member 2 isoform X5

UniProtKB/TrEMBL

A6JW06
XM_063267762.1 → XP_063123832.1 dnaJ homolog subfamily B member 2 isoform X7

UniProtKB/TrEMBL

A6JW05, A6JW06, D4ABC2
XM_063267754.1 → XP_063123824.1 dnaJ homolog subfamily B member 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A5U2, A6JW06
XM_063267757.1 → XP_063123827.1 dnaJ homolog subfamily B member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A3U5, A6JW06
XM_063267761.1 → XP_063123831.1 dnaJ homolog subfamily B member 2 isoform X6

UniProtKB/TrEMBL

A6JW06, B2RYA8