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    Hcfc1r1 host cell factor C1 regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287097, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hcfc1r1provided by RGD
    Official Full Name
    host cell factor C1 regulator 1provided by RGD
    Primary source
    RGD:727975
    See related
    AllianceGenome:RGD:727975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hpip
    Summary
    Predicted to be located in nucleoplasm. Orthologous to human HCFC1R1 (host cell factor C1 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 332.0), Kidney (RPKM 183.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hcfc1r1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13209757..13211445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12705139..12706852)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12994229..12995674)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene uncharacterized LOC102557038 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene THO complex subunit 6 Neighboring gene TNF receptor superfamily member 12A Neighboring gene claudin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    host cell factor C1 regulator 1
    Names
    HCF-1 beta-propeller-interacting protein
    host cell factor C1 regulator 1 (XPO1-dependent)
    inhibitor of four 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100492.1 → NP_001093962.1  host cell factor C1 regulator 1

      See identical proteins and their annotated locations for NP_001093962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY245001, BC168753, BG373213, FM050402
      UniProtKB/Swiss-Prot
      Q80V38
      UniProtKB/TrEMBL
      A6HCK4, A6HCK7
      Conserved Domains (1) summary
      pfam15226
      Location:2 → 112
      HPIP; HCF-1 beta-propeller-interacting protein family

    2. NM_001185047.1 → NP_001171976.1  host cell factor C1 regulator 1

      See identical proteins and their annotated locations for NP_001171976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC168753, BG373213, CB698538
      UniProtKB/Swiss-Prot
      Q80V38
      UniProtKB/TrEMBL
      A6HCK4, A6HCK7
      Conserved Domains (1) summary
      pfam15226
      Location:2 → 112
      HPIP; HCF-1 beta-propeller-interacting protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13209757..13211445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085345.2 → XP_038941273.1  host cell factor C1 regulator 1 isoform X1

      Conserved Domains (1) summary
      pfam15226
      Location:60 → 127
      HPIP; HCF-1 beta-propeller-interacting protein family

    2. XM_039085346.2 → XP_038941274.1  host cell factor C1 regulator 1 isoform X2

      UniProtKB/Swiss-Prot
      Q80V38
      UniProtKB/TrEMBL
      A6HCK4, A6HCK7
      Conserved Domains (1) summary
      pfam15226
      Location:2 → 112
      HPIP; HCF-1 beta-propeller-interacting protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V38.2 GenPept UniProtKB/Swiss-Prot:Q80V38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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