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    Coq2 coenzyme Q2, polyprenyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498332, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Coq2provided by RGD
    Official Full Name
    coenzyme Q2, polyprenyltransferaseprovided by RGD
    Primary source
    RGD:1306722
    See related
    Ensembl:ENSRNOG00000002194 AllianceGenome:RGD:1306722
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHB:PPT; RGD1306722
    Summary
    Predicted to enable 4-hydroxybenzoate decaprenyltransferase activity. Predicted to be involved in glycerol metabolic process and ubiquinone biosynthetic process. Predicted to be integral component of mitochondrial inner membrane. Biomarker of glucose intolerance. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 227.2), Muscle (RPKM 225.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9245777..9265784)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (8941429..8961418)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10581102..10601093)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352710 Neighboring gene heparanase Neighboring gene peptidylprolyl isomerase D, pseudogene 10 Neighboring gene uncharacterized LOC120096567 Neighboring gene nuclear receptor-binding factor 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, et al. Mamm Genome, 2015 Dec. PMID 26296322
    2. The COQ2 genotype predicts the severity of coenzyme Q10 deficiency. Desbats MA, et al. Hum Mol Genet, 2016 Oct 1. PMID 27493029
    3. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. López-Martín JM, et al. Hum Mol Genet, 2007 May 1. PMID 17374725, Free PMC Article
    4. A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Quinzii C, et al. Am J Hum Genet, 2006 Feb. PMID 16400613, Free PMC Article
    5. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ. Forsgren M, et al. Biochem J, 2004 Sep 1. PMID 15153069, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are differentially expressed in obese rats, suggesting that these two genes are candidates for the onset of type 2 diabetes associated with obesity in rats.
      Title: New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124824

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-hydroxybenzoate decaprenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxybenzoate decaprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-hydroxybenzoate decaprenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-hydroxybenzoate decaprenyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 4-hydroxybenzoate nonaprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-hydroxybenzoate octaprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
    Names
    4-HB polyprenyltransferase
    PHB:polyprenyltransferase
    coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
    coenzyme Q2 homolog, prenyltransferase
    para-hydroxybenzoate--polyprenyltransferase, mitochondrial
    NP_001037720.1
    XP_006250737.1
    XP_038948205.1
    XP_038948207.1
    XP_038948208.1
    XP_038948209.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044255.1 → NP_001037720.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001037720.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099827
      UniProtKB/Swiss-Prot
      Q499N4
      UniProtKB/TrEMBL
      A6K5Y9, G3V698
      Related
      ENSRNOP00000002987.4, ENSRNOT00000002987.5
      Conserved Domains (1) summary
      cl00337
      Location:68 → 353
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9245777..9265784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250675.5 → XP_006250737.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6K5Y9, G3V698
      Conserved Domains (1) summary
      cl00337
      Location:68 → 290
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    2. XM_039092279.2 → XP_038948207.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00337
      Location:68 → 181
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    3. XM_039092280.2 → XP_038948208.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00337
      Location:68 → 181
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    4. XM_039092277.2 → XP_038948205.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00337
      Location:68 → 211
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    5. XM_039092281.2 → XP_038948209.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl00337
      Location:68 → 210
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    RNA

    1. XR_005492997.2 RNA Sequence

    2. XR_010057400.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499N4.1 GenPept UniProtKB/Swiss-Prot:Q499N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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