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    Rab2b RAB2B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305853, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab2bprovided by RGD
    Official Full Name
    RAB2B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1309117
    See related
    Ensembl:ENSRNOG00000012488 AllianceGenome:RGD:1309117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in positive regulation of exocytosis. Located in presynapse. Orthologous to human RAB2B (RAB2B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 97.1), Kidney (RPKM 81.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27441860..27462479, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24968364..24988990, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28675504..28696192, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene ribosomal protein L9, pseudogene 29 Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene small nucleolar RNA, C/D box 8 Neighboring gene U6 spliceosomal RNA Neighboring gene Small nucleolar RNA SNORA72 Neighboring gene TOX high mobility group box family member 4 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab27a and Rab27b control different steps of the exosome secretion pathway. Ostrowski M, et al. Nat Cell Biol, 2010 Jan. PMID 19966785
    2. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, et al. J Neurosci, 2010 Oct 6. PMID 20926670, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125131

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-2B
    NP_001032734.1
    XP_038949207.1
    XP_038949210.1
    XP_063130300.1
    XP_063130301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037645.1 → NP_001032734.1  ras-related protein Rab-2B

      See identical proteins and their annotated locations for NP_001032734.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107443
      UniProtKB/TrEMBL
      A0A8I6G3N4, A6KEG9, A6KEH0, Q3B7V5
      Related
      ENSRNOP00000057211.2, ENSRNOT00000060467.5
      Conserved Domains (1) summary
      PLN03108
      Location:1 → 215
      PLN03108; Rab family protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27441860..27462479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093282.2 → XP_038949210.1  ras-related protein Rab-2B isoform X4

      Conserved Domains (1) summary
      PLN03108
      Location:1 → 119
      PLN03108; Rab family protein; Provisional

    2. XM_039093279.2 → XP_038949207.1  ras-related protein Rab-2B isoform X3

      UniProtKB/TrEMBL
      A0A8I6A284
      Related
      ENSRNOP00000084964.1
      Conserved Domains (1) summary
      cl38936
      Location:3 → 120
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063274231.1 → XP_063130301.1  ras-related protein Rab-2B isoform X2

    4. XM_063274230.1 → XP_063130300.1  ras-related protein Rab-2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKQ1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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