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    Gas8 Growth arrest specific protein 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31321, updated on 10-May-2024

    Summary

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    Official Symbol
    Gas8provided by FlyBase
    Official Full Name
    Growth arrest specific protein 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0029667
    Locus tag
    Dmel_CG14271
    See related
    AllianceGenome:FB:FBgn0029667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14271; Dmel\CG14271; GAS8
    Summary
    Predicted to enable microtubule binding activity and small GTPase binding activity. Predicted to be involved in cellular protein localization and flagellated sperm motility. Predicted to be located in motile cilium. Predicted to be active in Golgi apparatus and microtubule. Is expressed in chordotonal neurons; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gas8 in Genome Data Viewer
    Location:
    3D4-3D4; 1-3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3491011..3504851, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3385044..3398884, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dpr-interacting protein alpha Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR34335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. Yeh SD, et al. J Biol Chem, 2002 Feb 22. PMID 11751847
    2. A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population. Lange JD, et al. Mol Biol Evol, 2022 Feb 3. PMID 34971382, Free PMC Article
    3. Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Dorus S, et al. Nat Genet, 2006 Dec. PMID 17099714
    4. The Drosophila melanogaster sperm proteome-II (DmSP-II). Wasbrough ER, et al. J Proteomics, 2010 Oct 10. PMID 20833280
    5. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c3502247-3493147 mobile_element_type = transposon:roo{}37

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    growth arrest specific protein 8
    Names
    CG14271-PB
    CG14271-PC
    CG14271-PD
    Gas8-PB
    Gas8-PC
    Gas8-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3491011..3504851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297912.1 → NP_001284841.1  growth arrest specific protein 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT08, Q8T9R5, Q9W4R6
      UniProtKB/TrEMBL
      X2JI73
      Conserved Domains (1) summary
      pfam13851
      Location:221 → 421
      GAS; Growth-arrest specific micro-tubule binding

    2. NM_001297911.1 → NP_001284840.1  growth arrest specific protein 8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCG2
      Conserved Domains (1) summary
      pfam13851
      Location:196 → 396
      GAS; Growth-arrest specific micro-tubule binding

    3. NM_130709.2 → NP_570065.2  growth arrest specific protein 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570065.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT08, Q8T9R5, Q9W4R6
      UniProtKB/TrEMBL
      X2JI73
      Related
      FBpp0070564
      Conserved Domains (1) summary
      pfam13851
      Location:221 → 421
      GAS; Growth-arrest specific micro-tubule binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MT08.1 Q8MT08
    X2JCG2 X2JCG2
    X2JI73 X2JI73

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