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    SFT2 Sft2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852172, updated on 27-Jan-2024

    Summary

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    Gene symbol
    SFT2
    Gene description
    Sft2p
    Primary source
    SGD:S000000198
    Locus tag
    YBL102W
    See related
    AllianceGenome:SGD:S000000198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in retrograde transport, endosome to Golgi. Located in Golgi membrane and Golgi trans cisterna. Orthologous to several human genes including SFT2D3 (SFT2 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (24098..24745)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sea4p Neighboring gene Rtg3p Neighboring gene Ecm21p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A SNARE-like protein required for traffic through the Golgi complex. Banfield DK, et al. Nature, 1995 Jun 29. PMID 7596416
    2. The dynamics of golgi protein traffic visualized in living yeast cells. Wooding S, et al. Mol Biol Cell, 1998 Sep. PMID 9725919, Free PMC Article
    3. Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments. Liu YW, et al. Mol Biol Cell, 2005 Sep. PMID 15975906, Free PMC Article
    4. Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. Conchon S, et al. EMBO J, 1999 Jul 15. PMID 10406798, Free PMC Article
    5. The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae. Zou S, et al. Mol Cells, 2017 Sep 30. PMID 28927260, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sft2p
    NP_009448.1
    • Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      24098..24745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178342.1 → NP_009448.1  TPA: Sft2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPQ1, P38166
      UniProtKB/TrEMBL
      A0A6A5PZL4, A6ZKK2, B3LNN2, B5VDP3, C7GSE3, C8Z3T9, G2W8R2, N1PAX5
      Conserved Domains (1) summary
      COG5102
      Location:7 → 214
      SFT2; Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38166.1

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