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    CIN2 GTPase-activating protein CIN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855835, updated on 13-Apr-2024

    Summary

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    Gene symbol
    CIN2
    Gene description
    GTPase-activating protein CIN2
    Primary source
    SGD:S000006162
    Locus tag
    YPL241C
    See related
    AllianceGenome:SGD:S000006162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in protein folding and tubulin complex assembly. Predicted to be located in microtubule. Predicted to be active in cytoplasm. Used to study retinitis pigmentosa. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (95372..96258, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene signal recognition particle subunit SRP68 Neighboring gene Iqg1p Neighboring gene Hsp90 family chaperone HSP82 Neighboring gene Yar1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt MA, et al. Mol Cell Biol, 1990 Jan. PMID 2403635, Free PMC Article
    2. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Nithianantham S, et al. Elife, 2015 Jul 24. PMID 26208336, Free PMC Article
    3. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Stearns T, et al. Genetics, 1990 Feb. PMID 2407611, Free PMC Article
    4. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. Berlin V, et al. J Cell Biol, 1990 Dec. PMID 2277073, Free PMC Article
    5. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Veltel S, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18376416

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein CIN2
    NP_015083.1
    • GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      95372..96258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184055.1 → NP_015083.1  TPA: GTPase-activating protein CIN2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3D0, P46670, Q08973
      UniProtKB/TrEMBL
      A6ZW15, B3LKJ1, C8ZID8, G2WNU5, N1NXN5
      Conserved Domains (1) summary
      cl29757
      Location:118 → 220
      TBCC; Tubulin binding cofactor C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5CYA_A.1
    5CYA_B.1
    P46670.2

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