DGA1 diacylglycerol O-acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: DGA1
Gene description: diacylglycerol O-acyltransferase
Primary source: SGD:S000005771
Locus tag: YOR245C
See related: AllianceGenome:SGD:S000005771
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables diacylglycerol O-acyltransferase activity. Involved in several processes, including cellular triglyceride homeostasis; lipid storage; and triglyceride biosynthetic process. Located in lipid droplet. Is integral component of membrane. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including DGAT2 (diacylglycerol O-acyltransferase 2); MOGAT1 (monoacylglycerol O-acyltransferase 1); and MOGAT2 (monoacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DGA1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (794076..795332, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Saccharomyces cerevisiae Delta9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
Title: Saccharomyces cerevisiae Δ9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
Triglyceride deficiency and diacylglycerol kinase1 activity lead to the upregulation of mevalonate pathway in yeast: A study for the development of potential yeast platform for improved production of triterpenoid.
Title: Triglyceride deficiency and diacylglycerol kinase1 activity lead to the upregulation of mevalonate pathway in yeast: A study for the development of potential yeast platform for improved production of triterpenoid.
Dga1 deficiency triggers fatty acid-mediated cell death.
Title: Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death.
Diacylglycerol acyltransferase activity was significantly increased in the Deltasnf2 disruptant strain overexpressing DGA1 as compared with the wild-type strain overexpressing DGA1
Title: DGA1 (diacylglycerol acyltransferase gene) overexpression and leucine biosynthesis significantly increase lipid accumulation in the Deltasnf2 disruptant of Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2-acylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: diacylglycerol O-acyltransferase

NP_014888.1

EC 2.3.1.20

EC 2.3.1.22

Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

794076..795332 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183664.1 → NP_014888.1 TPA: diacylglycerol O-acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014888.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2U7, Q08650

UniProtKB/TrEMBL

A0A8H4F7D3, A6ZP84, B3LJR4, C8ZGZ7, N1NVW7

Conserved Domains (1) summary

cl17185
Location:80 → 410

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis