DSL1 Dsl1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: DSL1
Gene description: Dsl1p
Primary source: FungiDB:YNL258C
Locus tag: YNL258C
See related: SGD:S000005202; AllianceGenome:SGD:S000005202; VEuPathDB:YNL258C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RNS1
Summary: Involved in ER-dependent peroxisome organization and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum and nucleus. Part of Dsl1/NZR complex. Colocalizes with peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See DSL1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (158109..160373, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNARE-mediated homotypic ER fusion requires DSL1.
Title: ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway.
subunits of the Dsl1 complex (Dsl1, Dsl3, and Tip20), as well as the SNAREs Ufe1 and Sec20, are ER-resident proteins that do not seem to move into COPII vesicles.
Title: The Dsl1 protein tethering complex is a resident endoplasmic reticulum complex, which interacts with five soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptors (SNAREs): implications for fusion and fusion regulation.
a direct role of the Dsl1 complex, in particular Tip20p, in the formation and stabilization of ER SNARE complexes.
Title: The Dsl1 tethering complex actively participates in soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (SNARE) complex assembly at the endoplasmic reticulum in Saccharomyces cerevisiae.
Studies indicate that Dsl1 tethering complex seems to be designed to expose an unstructured domain of Dsl1p at its top, which is required to capture vesicles.
Title: Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules.
Study determined the structure of the Dsl1 complex, revealing a tower containing at its base the binding sites for two endoplasmic reticulum SNAREs and at its tip a flexible lasso for capturing vesicles.
Title: A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.
SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly
Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
Crystal structures show 2 of the 3 subunits, Tip20p and Dsl1p, resemble known subunits of the exocyst complex, establishing a structural connection among tethering complexes and implying that many of their subunits are derived from a common progenitor.
Title: Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.
DSL1 is required for the stable interaction of the SNARE Use1p with a central subcomplex consisting of Tip20p and the SNARE proteins Ufe1p and Sec20p.
Title: Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	IDA Inferred from Direct Assay more info	PubMed
part_of Dsl1/NZR complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Dsl1p

NP_014141.1

Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

158109..160373 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183096.1 → NP_014141.1 TPA: Dsl1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014141.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0T5, P53847

UniProtKB/TrEMBL

A0A8H4BVH2, A6ZRI5, C7GPA3, C8ZFX9

Conserved Domains (2) summary

pfam11989
Location:560 → 753

Dsl1_C; Retrograde transport protein Dsl1 C terminal

pfam11988
Location:6 → 360

Dsl1_N; Retrograde transport protein Dsl1 N terminal