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    GIS2 mRNA-binding translational activator GIS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855466, updated on 17-May-2024

    Summary

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    Gene symbol
    GIS2
    Gene description
    mRNA-binding translational activator GIS2
    Primary source
    FungiDB:YNL255C
    Locus tag
    YNL255C
    See related
    SGD:S000005199; AllianceGenome:SGD:S000005199; VEuPathDB:YNL255C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity; single-stranded DNA binding activity; and translation regulator activity. Involved in positive regulation of cytoplasmic translation. Located in P-body; cytoplasmic stress granule; and polysomal ribosome. Used to study myotonic dystrophy type 2. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GIS2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (167329..167790, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sip3p Neighboring gene trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 Neighboring gene Rtc4p Neighboring gene Tex1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. S phase block following MEC1ATR inactivation occurs without severe dNTP depletion. Earp C, et al. Biol Open, 2015 Nov 24. PMID 26603472, Free PMC Article
    2. The GIS2 Gene Is Repressed by a Zinc-Regulated Bicistronic RNA in Saccharomyces cerevisiae. Taggart J, et al. Genes (Basel), 2018 Sep 19. PMID 30235899, Free PMC Article
    3. Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules. Rojas M, et al. PLoS One, 2012. PMID 23285195, Free PMC Article
    4. The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. Tsvetanova NG, et al. PLoS Genet, 2012. PMID 22844259, Free PMC Article
    5. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Sen-Gupta M, et al. Yeast, 1997 Jul. PMID 9234673

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gis2 is a component of two large RNA-protein granules, processing bodies and stress granules, which contain translationally repressed mRNAs.
      Title: Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules.
    2. These data suggest that Gis2 is functionally orthologous to ZNF9 and acts as a cap-independent translation factor.
      Title: Saccharomyces cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-binding translational activator GIS2
    NP_014144.1
    • Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      167329..167790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183093.1 → NP_014144.1  TPA: mRNA-binding translational activator GIS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0T8, P53849
      UniProtKB/TrEMBL
      A0A6A5Q4J5, A6ZRI8, B3LP98, C7GPA6, C8ZFY2, G2WLL1, N1NZY3
      Conserved Domains (1) summary
      COG5082
      Location:1 → 129
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53849.1

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