Ikzf1 IKAROS family zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikzf1provided by MGI
Official Full Name: IKAROS family zinc finger 1provided by MGI
Primary source: MGI:MGI:1342540
See related: Ensembl:ENSMUSG00000018654 AllianceGenome:MGI:1342540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik
Summary: The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression: Biased expression in thymus adult (RPKM 67.8), spleen adult (RPKM 38.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 7.02 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (11634970..11722930)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (11684962..11772930)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ikaros is a principal regulator of Aire[+] mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
Title: Ikaros is a principal regulator of Aire(+) mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
Impaired tissue homing by the Ikzf3[N159S] variant is mediated by interfering with Ikaros function.
Title: Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function.
Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
Title: Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
Title: Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
Title: A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Title: An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
Title: Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
deletion of the E120 enhancer resulted in a significant reduction of Ikzf1 mRNA. However, the epigenetic landscape and 3D topology of the locus were only slightly affected, highlighting the complexity of the regulatory landscape regulating the Ikzf1 locus.
Title: Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.
Ikaros and Ikaros-induced enhancers are responsible for the cessation of proliferation and induction of T-cell differentiation in T-ALL cells
Title: Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity.
altered Ikaros expression in chronic lymphocytic leukemia or radioresistant B-1 cells could determine a responsive status of BCR to self-antigens, which would culminate in the clonal expansion of B-1 cells.
Title: Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Chemically induced (ENU) (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ikzf1 (e-PCR), detects polymorphism
- UniSTS:257034

Ikzf1 (e-PCR), detects polymorphism
- UniSTS:257035

Znfn1a1 (e-PCR), detects polymorphism
- UniSTS:158768

Ikzf1 (e-PCR), detects polymorphism
- UniSTS:534418

Ikzf1 (e-PCR), detects polymorphism
- UniSTS:534419

Ikzf1 (e-PCR), detects polymorphism
- UniSTS:547248

L03547 (e-PCR)
- UniSTS:124863

Znfn1a1 (e-PCR), detects polymorphism
- UniSTS:256457

PMC156063P1 (e-PCR)
- UniSTS:271357

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Peyer's patch development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal bipolar neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA-binding protein Ikaros

Names: ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein, subfamily 1A, 1 (Ikaros)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025597.3 → NP_001020768.1 DNA-binding protein Ikaros isoform 1

See identical proteins and their annotated locations for NP_001020768.1

Status: REVIEWED

Source sequence(s)

AL596450

Consensus CDS

CCDS24436.1

UniProtKB/TrEMBL

G5E8H3, Q571F4

Related

ENSMUSP00000075992.5, ENSMUST00000076700.11

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001301863.2 → NP_001288792.1 DNA-binding protein Ikaros isoform 1

See identical proteins and their annotated locations for NP_001288792.1

Status: REVIEWED

Source sequence(s)

AL596450

Consensus CDS

CCDS24436.1

UniProtKB/TrEMBL

G5E8H3, Q571F4

Related

ENSMUSP00000159473.1, ENSMUST00000240540.1

Conserved Domains (2) summary

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001301865.2 → NP_001288794.1 DNA-binding protein Ikaros isoform 2

See identical proteins and their annotated locations for NP_001288794.1

Status: REVIEWED

Source sequence(s)

AL596450

Consensus CDS

CCDS24437.1

UniProtKB/Swiss-Prot

Q03267, Q64044, Q64045, Q64051

UniProtKB/TrEMBL

Q5SWU0

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001301866.2 → NP_001288795.1 DNA-binding protein Ikaros isoform 3

See identical proteins and their annotated locations for NP_001288795.1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q3UQ33, Q5GGW5

Related

ENSMUSP00000159476.1, ENSMUST00000240543.1

Conserved Domains (4) summary

COG5048
Location:1 → 112

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:58 → 80

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:72 → 97

zf-H2C2_2; Zinc-finger double domain
NM_001301868.2 → NP_001288797.1 DNA-binding protein Ikaros isoform 4

See identical proteins and their annotated locations for NP_001288797.1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:143 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
NM_001404490.1 → NP_001391419.1 DNA-binding protein Ikaros isoform 5

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404491.1 → NP_001391420.1 DNA-binding protein Ikaros isoform 6

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404492.1 → NP_001391421.1 DNA-binding protein Ikaros isoform 7

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWT9
NM_001404493.1 → NP_001391422.1 DNA-binding protein Ikaros isoform 7

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWT9

Related

ENSMUSP00000067372.6, ENSMUST00000065433.12
NM_001404494.1 → NP_001391423.1 DNA-binding protein Ikaros isoform 7

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWT9
NM_001404495.1 → NP_001391424.1 DNA-binding protein Ikaros isoform 8

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404496.1 → NP_001391425.1 DNA-binding protein Ikaros isoform 9

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404497.1 → NP_001391426.1 DNA-binding protein Ikaros isoform 9

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404498.1 → NP_001391427.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404499.1 → NP_001391428.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404500.1 → NP_001391429.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404501.1 → NP_001391430.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404502.1 → NP_001391431.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404503.1 → NP_001391432.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404504.1 → NP_001391433.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404505.1 → NP_001391434.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404506.1 → NP_001391435.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

G5E8H3
NM_001404507.1 → NP_001391436.1 DNA-binding protein Ikaros isoform 4

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404508.1 → NP_001391437.1 DNA-binding protein Ikaros isoform 4

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404509.1 → NP_001391438.1 DNA-binding protein Ikaros isoform 4

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404510.1 → NP_001391439.1 DNA-binding protein Ikaros isoform 10

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404511.1 → NP_001391440.1 DNA-binding protein Ikaros isoform 32

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404512.1 → NP_001391441.1 DNA-binding protein Ikaros isoform 11

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404513.1 → NP_001391442.1 DNA-binding protein Ikaros isoform 12

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404514.1 → NP_001391443.1 DNA-binding protein Ikaros isoform 13

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404515.1 → NP_001391444.1 DNA-binding protein Ikaros isoform 14

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404516.1 → NP_001391445.1 DNA-binding protein Ikaros isoform 14

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404517.1 → NP_001391446.1 DNA-binding protein Ikaros isoform 14

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404518.1 → NP_001391447.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404519.1 → NP_001391448.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404520.1 → NP_001391449.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404521.1 → NP_001391450.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404522.1 → NP_001391451.1 DNA-binding protein Ikaros isoform 15

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404523.1 → NP_001391452.1 DNA-binding protein Ikaros isoform 16

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404524.1 → NP_001391453.1 DNA-binding protein Ikaros isoform 17

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404525.1 → NP_001391454.1 DNA-binding protein Ikaros isoform 18

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404526.1 → NP_001391455.1 DNA-binding protein Ikaros isoform 33

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404527.1 → NP_001391456.1 DNA-binding protein Ikaros isoform 19

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404531.1 → NP_001391460.1 DNA-binding protein Ikaros isoform 19

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404532.1 → NP_001391461.1 DNA-binding protein Ikaros isoform 19

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404533.1 → NP_001391462.1 DNA-binding protein Ikaros isoform 19

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404534.1 → NP_001391463.1 DNA-binding protein Ikaros isoform 20

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404535.1 → NP_001391464.1 DNA-binding protein Ikaros isoform 21

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404537.1 → NP_001391466.1 DNA-binding protein Ikaros isoform 22

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404539.1 → NP_001391468.1 DNA-binding protein Ikaros isoform 23

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404540.1 → NP_001391469.1 DNA-binding protein Ikaros isoform 23

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404542.1 → NP_001391471.1 DNA-binding protein Ikaros isoform 23

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404543.1 → NP_001391472.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWU0
NM_001404544.1 → NP_001391473.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWU0
NM_001404545.1 → NP_001391474.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWU0
NM_001404547.1 → NP_001391476.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWU0
NM_001404549.1 → NP_001391478.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q5SWU0
NM_001404550.1 → NP_001391479.1 DNA-binding protein Ikaros isoform 24

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404551.1 → NP_001391480.1 DNA-binding protein Ikaros isoform 24

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404552.1 → NP_001391481.1 DNA-binding protein Ikaros isoform 24

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404553.1 → NP_001391482.1 DNA-binding protein Ikaros isoform 25

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404554.1 → NP_001391483.1 DNA-binding protein Ikaros isoform 26

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404555.1 → NP_001391484.1 DNA-binding protein Ikaros isoform 3

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q3UQ33
NM_001404556.1 → NP_001391485.1 DNA-binding protein Ikaros isoform 3

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q3UQ33
NM_001404557.1 → NP_001391486.1 DNA-binding protein Ikaros isoform 3

Status: REVIEWED

Source sequence(s)

AL596450

UniProtKB/TrEMBL

Q3UQ33
NM_001404558.1 → NP_001391487.1 DNA-binding protein Ikaros isoform 27

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404559.1 → NP_001391488.1 DNA-binding protein Ikaros isoform 27

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404560.1 → NP_001391489.1 DNA-binding protein Ikaros isoform 27

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404561.1 → NP_001391490.1 DNA-binding protein Ikaros isoform 27

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404562.1 → NP_001391491.1 DNA-binding protein Ikaros isoform 28

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404563.1 → NP_001391492.1 DNA-binding protein Ikaros isoform 34

Status: REVIEWED

Source sequence(s)

AL596450

Related

ENSMUSP00000159477.1, ENSMUST00000240544.1
NM_001404564.1 → NP_001391493.1 DNA-binding protein Ikaros isoform 29

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404565.1 → NP_001391494.1 DNA-binding protein Ikaros isoform 30

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404567.1 → NP_001391496.1 DNA-binding protein Ikaros isoform 30

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404568.1 → NP_001391497.1 DNA-binding protein Ikaros isoform 30

Status: REVIEWED

Source sequence(s)

AL596450
NM_001404569.1 → NP_001391498.1 DNA-binding protein Ikaros isoform 31

Status: REVIEWED

Source sequence(s)

AL596450
NM_009578.4 → NP_033604.2 DNA-binding protein Ikaros isoform 2

See identical proteins and their annotated locations for NP_033604.2

Status: REVIEWED

Source sequence(s)

AL596450

Consensus CDS

CCDS24437.1

UniProtKB/Swiss-Prot

Q03267, Q64044, Q64045, Q64051

UniProtKB/TrEMBL

Q5SWU0

Related

ENSMUSP00000018798.7, ENSMUST00000018798.7

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

11634970..11722930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243705.2 → XP_011242007.1 DNA-binding protein Ikaros isoform X6

See identical proteins and their annotated locations for XP_011242007.1

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:179 → 527

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:155 → 175

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:168 → 192

zf-H2C2_2; Zinc-finger double domain
XM_011243711.2 → XP_011242013.1 DNA-binding protein Ikaros isoform X1

See identical proteins and their annotated locations for XP_011242013.1

UniProtKB/TrEMBL

Q571F4, Q5SWT9

Conserved Domains (3) summary

COG5048
Location:163 → 511

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011243701.3 → XP_011242003.1 DNA-binding protein Ikaros isoform X2

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:163 → 501

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011243707.3 → XP_011242009.1 DNA-binding protein Ikaros isoform X8

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:163 → 466

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011243706.3 → XP_011242008.1 DNA-binding protein Ikaros isoform X7

UniProtKB/TrEMBL

Q571F4

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011243713.3 → XP_011242015.1 DNA-binding protein Ikaros isoform X10

UniProtKB/Swiss-Prot

Q03267, Q64044, Q64045, Q64051

Conserved Domains (2) summary

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain
XM_011243703.3 → XP_011242005.1 DNA-binding protein Ikaros isoform X5

See identical proteins and their annotated locations for XP_011242005.1

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:143 → 481

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:119 → 139

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:132 → 156

zf-H2C2_2; Zinc-finger double domain
XM_011243716.2 → XP_011242018.1 DNA-binding protein Ikaros isoform X14

UniProtKB/Swiss-Prot

Q03267, Q64044, Q64045, Q64051

Conserved Domains (2) summary

COG5048
Location:1 → 131

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011243718.2 → XP_011242020.1 DNA-binding protein Ikaros isoform X17

UniProtKB/TrEMBL

Q5GGW5

Conserved Domains (4) summary

COG5048
Location:1 → 112

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:60 → 80

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:58 → 80

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:72 → 97

zf-H2C2_2; Zinc-finger double domain
XM_011243704.3 → XP_011242006.1 DNA-binding protein Ikaros isoform X6

See identical proteins and their annotated locations for XP_011242006.1

UniProtKB/TrEMBL

Q571F4

Conserved Domains (3) summary

COG5048
Location:179 → 527

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:155 → 175

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:168 → 192

zf-H2C2_2; Zinc-finger double domain
XM_011243710.4 → XP_011242012.1 DNA-binding protein Ikaros isoform X1

See identical proteins and their annotated locations for XP_011242012.1

UniProtKB/TrEMBL

Q571F4, Q5SWT9

Conserved Domains (3) summary

COG5048
Location:163 → 511

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:139 → 159

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:152 → 176

zf-H2C2_2; Zinc-finger double domain