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    Ppp1r3b protein phosphatase 1, regulatory subunit 3B [ Mus musculus (house mouse) ]

    Gene ID: 244416, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ppp1r3bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 3Bprovided by MGI
    Primary source
    MGI:MGI:2177268
    See related
    Ensembl:ENSMUSG00000046794 AllianceGenome:MGI:2177268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GL; PTG; 6430576E21
    Summary
    Predicted to enable several functions, including [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within regulation of glycogen catabolic process. Predicted to be located in glycogen granule and intracellular membrane-bounded organelle. Predicted to be part of protein phosphatase type 1 complex. Is expressed in several structures, including alimentary system; hindlimb mesenchyme; respiratory system; sensory organ; and urinary system. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 47.3), liver E18 (RPKM 22.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A4; 8 21.16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (35842847..35855293)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (35375694..35388139)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36313763-36314027 Neighboring gene predicted gene, 34647 Neighboring gene STARR-seq mESC enhancer starr_21182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36384665-36384970 Neighboring gene predicted gene, 34705 Neighboring gene predicted gene 45301 Neighboring gene predicted gene, 34911 Neighboring gene predicted gene, 51567

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis. Mehta MB, et al. J Biol Chem, 2017 Jun 23. PMID 28473467, Free PMC Article
    2. Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. Stender S, et al. Hepatology, 2018 Jun. PMID 29266543, Free PMC Article
    3. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. von Wilamowitz-Moellendorff A, et al. Diabetes, 2013 Dec. PMID 23990365, Free PMC Article
    4. Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells. Niimi T, et al. Biochem Biophys Res Commun, 2006 Oct 20. PMID 16949035
    5. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. Munro S, et al. Diabetes, 2002 Mar. PMID 11872655

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
      Title: mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
    2. Mice lacking protein phosphatase 1 regulatory subunit 3B (PPP1R3B) were deficient in hepatic glycogen, whereas HTGC was unchanged. Hepatic overexpression of PPP1R3B caused accumulation of hepatic glycogen and elevated plasma levels of ALT, but did not change HTGC
      Title: Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride.
    3. findings indicate a major role for Ppp1r3b in regulating hepatic glycogen stores and whole-body glucose/energy homeostasis.
      Title: Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.
    4. analysis of expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells
      Title: Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [phosphorylase] phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in glycogen granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 3B
    Names
    PP1 subunit R4
    hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
    protein phosphatase 1 regulatory subunit 4
    protein phosphatase 1, regulatory (inhibitor) subunit 3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364450.1 → NP_001351379.1  protein phosphatase 1 regulatory subunit 3B

      Status: VALIDATED

      Source sequence(s)
      BC079666, CD355429
      Consensus CDS
      CCDS22243.1
      UniProtKB/Swiss-Prot
      Q6PAJ7, Q8C767
      Related
      ENSMUSP00000147736.2, ENSMUST00000210337.2
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    2. NM_001364451.1 → NP_001351380.1  protein phosphatase 1 regulatory subunit 3B

      Status: VALIDATED

      Source sequence(s)
      AC159316
      Consensus CDS
      CCDS22243.1
      UniProtKB/Swiss-Prot
      Q6PAJ7, Q8C767
      Related
      ENSMUSP00000147633.2, ENSMUST00000211648.2
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    3. NM_001364452.1 → NP_001351381.1  protein phosphatase 1 regulatory subunit 3B

      Status: VALIDATED

      Source sequence(s)
      BC060261, BC079666, BY784264
      Consensus CDS
      CCDS22243.1
      UniProtKB/Swiss-Prot
      Q6PAJ7, Q8C767
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    4. NM_177741.4 → NP_808409.1  protein phosphatase 1 regulatory subunit 3B

      See identical proteins and their annotated locations for NP_808409.1

      Status: VALIDATED

      Source sequence(s)
      BC079666
      Consensus CDS
      CCDS22243.1
      UniProtKB/Swiss-Prot
      Q6PAJ7, Q8C767
      Related
      ENSMUSP00000065679.7, ENSMUST00000070481.8
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      35842847..35855293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312797.3 → XP_017168286.1  protein phosphatase 1 regulatory subunit 3B isoform X1

      UniProtKB/Swiss-Prot
      Q6PAJ7, Q8C767
      Conserved Domains (1) summary
      pfam03370
      Location:126 → 231
      CBM_21; Carbohydrate/starch-binding module (family 21)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C767.1 GenPept UniProtKB/Swiss-Prot:Q8C767

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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